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Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.
Scherer O, Steinmetz H, Kaether C, Weinigel C, Barz D, Kleinert H, Menche D, Müller R, Pergola C, Werz O. Scherer O, et al. Among authors: menche d. Biochem Pharmacol. 2014 Oct 15;91(4):490-500. doi: 10.1016/j.bcp.2014.07.028. Epub 2014 Aug 12. Biochem Pharmacol. 2014. PMID: 25107704 Free article.
Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase.
Thomas L, Rao Z, Gerstmeier J, Raasch M, Weinigel C, Rummler S, Menche D, Müller R, Pergola C, Mosig A, Werz O. Thomas L, et al. Among authors: menche d. Biochem Pharmacol. 2017 Apr 15;130:71-82. doi: 10.1016/j.bcp.2017.02.004. Epub 2017 Feb 9. Biochem Pharmacol. 2017. PMID: 28189727 Free article.
Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation.
Rao Z, Pace S, Jordan PM, Bilancia R, Troisi F, Börner F, Andreas N, Kamradt T, Menche D, Rossi A, Serhan CN, Gerstmeier J, Werz O. Rao Z, et al. Among authors: menche d. J Immunol. 2019 Aug 15;203(4):1031-1043. doi: 10.4049/jimmunol.1900236. Epub 2019 Jul 12. J Immunol. 2019. PMID: 31300512 Free PMC article.
Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells.
Wollnitzke P, Wagner R, Afsar SY, Werner M, Geschold R, Müller CE, Werz O, van Echten-Deckert G, Menche D. Wollnitzke P, et al. Among authors: menche d. Bioorg Med Chem Lett. 2023 Oct 1;94:129464. doi: 10.1016/j.bmcl.2023.129464. Epub 2023 Aug 25. Bioorg Med Chem Lett. 2023. PMID: 37634760
119 results