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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E. Nieman KM, et al. Among authors: romero il. Nat Med. 2011 Oct 30;17(11):1498-503. doi: 10.1038/nm.2492. Nat Med. 2011. PMID: 22037646 Free PMC article.
Adipose tissue and adipocytes support tumorigenesis and metastasis.
Nieman KM, Romero IL, Van Houten B, Lengyel E. Nieman KM, et al. Among authors: romero il. Biochim Biophys Acta. 2013 Oct;1831(10):1533-41. doi: 10.1016/j.bbalip.2013.02.010. Epub 2013 Mar 14. Biochim Biophys Acta. 2013. PMID: 23500888 Free PMC article. Review.
Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.
Chiyoda T, Hart PC, Eckert MA, McGregor SM, Lastra RR, Hamamoto R, Nakamura Y, Yamada SD, Olopade OI, Lengyel E, Romero IL. Chiyoda T, et al. Among authors: romero il. Cancer Prev Res (Phila). 2017 Apr;10(4):255-266. doi: 10.1158/1940-6207.CAPR-16-0281. Epub 2017 Mar 6. Cancer Prev Res (Phila). 2017. PMID: 28264838 Free PMC article.
SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
Hart PC, Chiyoda T, Liu X, Weigert M, Curtis M, Chiang CY, Loth R, Lastra R, McGregor SM, Locasale JW, Lengyel E, Romero IL. Hart PC, et al. Among authors: romero il. Mol Cancer Res. 2019 Apr;17(4):870-881. doi: 10.1158/1541-7786.MCR-18-0409. Epub 2019 Jan 17. Mol Cancer Res. 2019. PMID: 30655321 Free PMC article.
Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.
Zillhardt M, Park SM, Romero IL, Sawada K, Montag A, Krausz T, Yamada SD, Peter ME, Lengyel E. Zillhardt M, et al. Among authors: romero il. Clin Cancer Res. 2011 Jun 15;17(12):4042-51. doi: 10.1158/1078-0432.CCR-10-3387. Epub 2011 May 6. Clin Cancer Res. 2011. PMID: 21551255 Free PMC article.
52 results