Kleiger G - Search Results

1

NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.

Baek K, Krist DT, Prabu JR, Hill S, Klügel M, Neumaier LM, von Gronau S, Kleiger G, Schulman BA. Baek K, et al. Among authors: kleiger g. Nature. 2020 Feb;578(7795):461-466. doi: 10.1038/s41586-020-2000-y. Epub 2020 Feb 12. Nature. 2020. PMID: 32051583 Free PMC article.

2

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

den Besten W, Verma R, Kleiger G, Oania RS, Deshaies RJ. den Besten W, et al. Among authors: kleiger g. Nat Struct Mol Biol. 2012 Apr 1;19(5):511-6, S1. doi: 10.1038/nsmb.2269. Nat Struct Mol Biol. 2012. PMID: 22466964 Free PMC article.

3

Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails.

Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G. Ziemba A, et al. Among authors: kleiger g. J Biol Chem. 2013 Nov 29;288(48):34882-96. doi: 10.1074/jbc.M113.509190. Epub 2013 Oct 15. J Biol Chem. 2013. PMID: 24129577 Free PMC article.

4

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F. Huang H, et al. Among authors: kleiger g. Nat Chem Biol. 2014 Feb;10(2):156-163. doi: 10.1038/nchembio.1412. Epub 2013 Dec 15. Nat Chem Biol. 2014. PMID: 24316736 Free PMC article.

5

Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.

Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G. Sandoval D, et al. Among authors: kleiger g. J Biol Chem. 2015 Jan 9;290(2):1106-18. doi: 10.1074/jbc.M114.615559. Epub 2014 Nov 25. J Biol Chem. 2015. PMID: 25425648 Free PMC article.

6

Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.

Hill S, Harrison JS, Lewis SM, Kuhlman B, Kleiger G. Hill S, et al. Among authors: kleiger g. Mol Cell Biol. 2016 May 16;36(11):1720-32. doi: 10.1128/MCB.00097-16. Print 2016 Jun 1. Mol Cell Biol. 2016. PMID: 27044868 Free PMC article.

7

The San1 Ubiquitin Ligase Functions Preferentially with Ubiquitin-conjugating Enzyme Ubc1 during Protein Quality Control.

Ibarra R, Sandoval D, Fredrickson EK, Gardner RG, Kleiger G. Ibarra R, et al. Among authors: kleiger g. J Biol Chem. 2016 Sep 2;291(36):18778-90. doi: 10.1074/jbc.M116.737619. Epub 2016 Jul 12. J Biol Chem. 2016. PMID: 27405755 Free PMC article.

8

Tag Team Ubiquitin Ligases.

Kleiger G, Deshaies R. Kleiger G, et al. Cell. 2016 Aug 25;166(5):1080-1081. doi: 10.1016/j.cell.2016.08.014. Cell. 2016. PMID: 27565338 Free article.

9

Self-regulating ubiquitin ligases.

Hill S, Kleiger G. Hill S, et al. Among authors: kleiger g. EMBO J. 2017 Feb 15;36(4):392-393. doi: 10.15252/embj.201696154. Epub 2017 Jan 13. EMBO J. 2017. PMID: 28087580 Free PMC article.

10

Using In Vitro Ubiquitylation Assays to Estimate the Affinities of Ubiquitin-Conjugating Enzymes for Their Ubiquitin Ligase Partners.

Hill S, Hill C, Kleiger G. Hill S, et al. Among authors: kleiger g. Methods Mol Biol. 2018;1844:39-58. doi: 10.1007/978-1-4939-8706-1_4. Methods Mol Biol. 2018. PMID: 30242702

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