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Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity.
Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, Roper DI, Lloyd AJ, Dowson CG, Cheng TJ, Cheng WC, Demon D, Meyer E, Meutermans W, Cooper MA. Zuegg J, et al. Among authors: galley nf. Nat Commun. 2015 Jul 21;6:7719. doi: 10.1038/ncomms8719. Nat Commun. 2015. PMID: 26194781 Free PMC article.
Clostridioides difficile canonical L,D-transpeptidases catalyze a novel type of peptidoglycan cross-links and are not required for beta-lactam resistance.
Galley NF, Greetham D, Alamán-Zárate MG, Williamson MP, Evans CA, Spittal WD, Buddle JE, Freeman J, Davis GL, Dickman MJ, Wilcox MH, Lovering AL, Fagan RP, Mesnage S. Galley NF, et al. J Biol Chem. 2024 Jan;300(1):105529. doi: 10.1016/j.jbc.2023.105529. Epub 2023 Dec 1. J Biol Chem. 2024. PMID: 38043796 Free PMC article.