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Page 1
Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data.
Viney NJ, Guo S, Tai LJ, Baker BF, Aghajan M, Jung SW, Yu RZ, Booten S, Murray H, Machemer T, Burel S, Murray S, Buchele G, Tsimikas S, Schneider E, Geary RS, Benson MD, Monia BP. Viney NJ, et al. Among authors: buchele g. ESC Heart Fail. 2021 Feb;8(1):652-661. doi: 10.1002/ehf2.13154. Epub 2020 Dec 7. ESC Heart Fail. 2021. PMID: 33283485 Free PMC article. Clinical Trial.
Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy.
Coelho T, Ando Y, Benson MD, Berk JL, Waddington-Cruz M, Dyck PJ, Gillmore JD, Khella SL, Litchy WJ, Obici L, Monteiro C, Tai LJ, Viney NJ, Buchele G, Brambatti M, Jung SW, St L O'Dea L, Tsimikas S, Schneider E, Geary RS, Monia BP, Gertz M. Coelho T, et al. Among authors: buchele g. Neurol Ther. 2021 Jun;10(1):375-389. doi: 10.1007/s40120-021-00235-6. Epub 2021 Feb 26. Neurol Ther. 2021. PMID: 33638113 Free PMC article.
Enabling patient-reported outcome measures in clinical trials, exemplified by cardiovascular trials.
Coles TM, Hernandez AF, Reeve BB, Cook K, Edwards MC, Boutin M, Bush E, Degboe A, Roessig L, Rudolph A, McNulty P, Patel N, Kay-Mugford T, Vernon M, Woloschak M, Buchele G, Spertus JA, Roe MT, Bury D, Weinfurt K. Coles TM, et al. Among authors: buchele g. Health Qual Life Outcomes. 2021 Jun 13;19(1):164. doi: 10.1186/s12955-021-01800-1. Health Qual Life Outcomes. 2021. PMID: 34120618 Free PMC article.
Prevention at home in older persons with (pre-)frailty: analysis of participants' recruitment and characteristics of the randomized controlled PromeTheus trial.
Fleiner T, Nerz C, Denkinger M, Bauer JM, Grüneberg C, Dams J, Schäufele M, Büchele G; PromeTheus Study Group. Fleiner T, et al. Among authors: buchele g. Aging Clin Exp Res. 2024 May 23;36(1):120. doi: 10.1007/s40520-024-02775-x. Aging Clin Exp Res. 2024. PMID: 38780837 Free PMC article. Clinical Trial.
Multimodal home-based rehabilitation intervention after discharge from inpatient geriatric rehabilitation (GeRas): study protocol for a multicenter randomized controlled trial.
Abel B, Bongartz M, Rapp K, Roigk P, Peiter J, Metz B, Finger B, Büchele G, Wensing M, Roth C, Schmidberger O, König HH, Gottschalk S, Dams J, Deuster O, Immel D, Micol W, Bauer JM, Benzinger P. Abel B, et al. Among authors: buchele g. BMC Geriatr. 2024 Jan 17;24(1):69. doi: 10.1186/s12877-023-04634-2. BMC Geriatr. 2024. PMID: 38233746 Free PMC article.
[Cooperation of geriatrics and trauma surgery in certified geriatric trauma centers : Insights into different care models and the implementation of requirements resulting from certification].
Roigk P, Becker C, Pfeiffer K, Bühl K, Büchele G, Rothenbacher D, König HH, Konnopka C, Fries T, Rapp K. Roigk P, et al. Among authors: buchele g. Z Gerontol Geriatr. 2024 Jan 12. doi: 10.1007/s00391-023-02271-3. Online ahead of print. Z Gerontol Geriatr. 2024. PMID: 38214754 German.
Eplontersen for Hereditary Transthyretin Amyloidosis With Polyneuropathy.
Coelho T, Marques W Jr, Dasgupta NR, Chao CC, Parman Y, França MC Jr, Guo YC, Wixner J, Ro LS, Calandra CR, Kowacs PA, Berk JL, Obici L, Barroso FA, Weiler M, Conceição I, Jung SW, Buchele G, Brambatti M, Chen J, Hughes SG, Schneider E, Viney NJ, Masri A, Gertz MR, Ando Y, Gillmore JD, Khella S, Dyck PJB, Waddington Cruz M; NEURO-TTRansform Investigators. Coelho T, et al. Among authors: buchele g. JAMA. 2023 Oct 17;330(15):1448-1458. doi: 10.1001/jama.2023.18688. JAMA. 2023. PMID: 37768671 Free PMC article.
132 results