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A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis.
EMBO Rep. 2020 Mar 4;21(3):e49254. doi: 10.15252/embr.201949254. Epub 2020 Feb 3.
EMBO Rep. 2020.
PMID: 32009295
Free PMC article.
The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB.
Roberts JZ, et al. Among authors: humphreys lm.
Cell Death Differ. 2020 Sep;27(9):2726-2741. doi: 10.1038/s41418-020-0539-7. Epub 2020 Apr 20.
Cell Death Differ. 2020.
PMID: 32313199
Free PMC article.
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FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer.
McLaughlin KA, Nemeth Z, Bradley CA, Humphreys L, Stasik I, Fenning C, Majkut J, Higgins C, Crawford N, Holohan C, Johnston PG, Harrison T, Hanna GG, Butterworth KT, Prise KM, Longley DB.
McLaughlin KA, et al.
Mol Cancer Ther. 2016 Oct;15(10):2432-2441. doi: 10.1158/1535-7163.MCT-16-0211. Epub 2016 Jul 29.
Mol Cancer Ther. 2016.
PMID: 27474150
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FLIP as a therapeutic target in cancer.
Humphreys L, Espona-Fiedler M, Longley DB.
Humphreys L, et al.
FEBS J. 2018 Nov;285(22):4104-4123. doi: 10.1111/febs.14523. Epub 2018 Jun 27.
FEBS J. 2018.
PMID: 29806737
Free article.
Review.
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The role of E3 ubiquitin ligases in the development and progression of glioblastoma.
Humphreys LM, Smith P, Chen Z, Fouad S, D'Angiolella V.
Humphreys LM, et al.
Cell Death Differ. 2021 Feb;28(2):522-537. doi: 10.1038/s41418-020-00696-6. Epub 2021 Jan 11.
Cell Death Differ. 2021.
PMID: 33432111
Free PMC article.
Review.
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Nutritional deficiency post esophageal and gastric cancer surgery: A quality improvement study.
Veeralakshmanan P, Tham JC, Wright A, Bolter M, Wadhawan H, Humphreys LM, Sanders G, Wheatley T, Berrisford RJ, Ariyarathenam A.
Veeralakshmanan P, et al. Among authors: humphreys lm.
Ann Med Surg (Lond). 2020 May 29;56:19-22. doi: 10.1016/j.amsu.2020.05.032. eCollection 2020 Aug.
Ann Med Surg (Lond). 2020.
PMID: 32566222
Free PMC article.
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Detection of asymptomatic adenocarcinoma at endoscopy prior to gastric banding justifies routine endoscopy.
Humphreys LM, Meredith H, Morgan J, Norton S.
Humphreys LM, et al.
Obes Surg. 2012 Apr;22(4):594-6. doi: 10.1007/s11695-011-0506-y.
Obes Surg. 2012.
PMID: 21887608
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