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The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB. Roberts JZ, et al. Cell Death Differ. 2020 Sep;27(9):2726-2741. doi: 10.1038/s41418-020-0539-7. Epub 2020 Apr 20. Cell Death Differ. 2020. PMID: 32313199 Free PMC article.
DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models.
Johnston MC, Nicoll JA, Redmond KM, Smyth P, Greene MK, McDaid WJ, Chan DKW, Crawford N, Stott KJ, Fox JP, Straubinger NL, Roche S, Clynes M, Straubinger RM, Longley DB, Scott CJ. Johnston MC, et al. Among authors: fox jp. J Control Release. 2020 Aug 10;324:610-619. doi: 10.1016/j.jconrel.2020.05.046. Epub 2020 Jun 3. J Control Release. 2020. PMID: 32504778 Free PMC article.
Therapeutics Targeting the Core Apoptotic Machinery.
Hamilton C, Fox JP, Longley DB, Higgins CA. Hamilton C, et al. Among authors: fox jp. Cancers (Basel). 2021 May 26;13(11):2618. doi: 10.3390/cancers13112618. Cancers (Basel). 2021. PMID: 34073507 Free PMC article. Review.
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Crawford N, Stott KJ, Sessler T, McCann C, McDaid W, Lees A, Latimer C, Fox JP, Munck JM, Smyth T, Shah A, Martins V, Lawler M, Dunne PD, Kerr EM, McDade SS, Coyle VM, Longley DB. Crawford N, et al. Among authors: fox jp. Mol Cancer Ther. 2021 Sep;20(9):1627-1639. doi: 10.1158/1535-7163.MCT-20-1050. Epub 2021 Aug 13. Mol Cancer Ther. 2021. PMID: 34389694 Free PMC article.
239 results