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An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson's Disease and G2019S LRRK2 Cohorts.
Padmanabhan S, Lanz TA, Gorman D, Wolfe M, Joyce A, Cabrera C, Lawrence-Henderson R, Levers N, Joshi N, Ma TC, Liong C, Narayan S, Alcalay RN, Hutten SJ, Baptista MAS, Merchant K. Padmanabhan S, et al. Among authors: lanz ta. J Parkinsons Dis. 2020;10(2):623-629. doi: 10.3233/JPD-191786. J Parkinsons Dis. 2020. PMID: 32007961 Free PMC article.
LRRK2 activation in idiopathic Parkinson's disease.
Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT. Di Maio R, et al. Among authors: lanz ta. Sci Transl Med. 2018 Jul 25;10(451):eaar5429. doi: 10.1126/scitranslmed.aar5429. Sci Transl Med. 2018. PMID: 30045977 Free PMC article.
Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575).
Lanz TA, Hosley JD, Adams WJ, Merchant KM. Lanz TA, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):49-55. doi: 10.1124/jpet.103.060715. Epub 2004 Jan 12. J Pharmacol Exp Ther. 2004. PMID: 14718585
Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease.
Kleiman RJ, Kimmel LH, Bove SE, Lanz TA, Harms JF, Romegialli A, Miller KS, Willis A, des Etages S, Kuhn M, Schmidt CJ. Kleiman RJ, et al. Among authors: lanz ta. J Pharmacol Exp Ther. 2011 Jan;336(1):64-76. doi: 10.1124/jpet.110.173294. Epub 2010 Oct 5. J Pharmacol Exp Ther. 2011. PMID: 20923867
39 results