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Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.
Sharma M, Khong H, Fa'ak F, Bentebibel SE, Janssen LME, Chesson BC, Creasy CA, Forget MA, Kahn LMS, Pazdrak B, Karki B, Hailemichael Y, Singh M, Vianden C, Vennam S, Bharadwaj U, Tweardy DJ, Haymaker C, Bernatchez C, Huang S, Rajapakshe K, Coarfa C, Hurwitz ME, Sznol M, Hwu P, Hoch U, Addepalli M, Charych DH, Zalevsky J, Diab A, Overwijk WW. Sharma M, et al. Among authors: singh m. Nat Commun. 2020 Jan 31;11(1):661. doi: 10.1038/s41467-020-14471-1. Nat Commun. 2020. PMID: 32005826 Free PMC article. Clinical Trial.
Intratumoral immunotherapy for melanoma.
Singh M, Overwijk WW. Singh M, et al. Cancer Immunol Immunother. 2015 Jul;64(7):911-21. doi: 10.1007/s00262-015-1727-z. Epub 2015 Jun 7. Cancer Immunol Immunother. 2015. PMID: 26050024 Free PMC article. Review.
Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.
Hailemichael Y, Woods A, Fu T, He Q, Nielsen MC, Hasan F, Roszik J, Xiao Z, Vianden C, Khong H, Singh M, Sharma M, Faak F, Moore D, Dai Z, Anthony SM, Schluns KS, Sharma P, Engelhard VH, Overwijk WW. Hailemichael Y, et al. Among authors: singh m. J Clin Invest. 2018 Apr 2;128(4):1338-1354. doi: 10.1172/JCI93303. Epub 2018 Feb 26. J Clin Invest. 2018. PMID: 29480817 Free PMC article.
Vaccinating with Stem Cells to Stop Cancer.
Hailemichael Y, Singh M, Overwijk W. Hailemichael Y, et al. Among authors: singh m. Trends Mol Med. 2018 Jun;24(6):524-526. doi: 10.1016/j.molmed.2018.04.006. Epub 2018 May 3. Trends Mol Med. 2018. PMID: 29731352
IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma.
Singh S, Xiao Z, Bavisi K, Roszik J, Melendez BD, Wang Z, Cantwell MJ, Davis RE, Lizee G, Hwu P, Neelapu SS, Overwijk WW, Singh M. Singh S, et al. Among authors: singh m. J Immunol. 2021 Apr 15;206(8):1966-1975. doi: 10.4049/jimmunol.2000523. Epub 2021 Mar 15. J Immunol. 2021. PMID: 33722878 Free PMC article.
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