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The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling.
J Biol Chem. 2020 Feb 28;295(9):2866-2884. doi: 10.1074/jbc.RA119.010077. Epub 2020 Jan 20.
J Biol Chem. 2020.
PMID: 31959628
Free PMC article.
A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.
Tetley GJN, Mott HR, Cooley RN, Owen D.
Tetley GJN, et al.
J Biol Chem. 2017 Jul 7;292(27):11361-11373. doi: 10.1074/jbc.M117.789883. Epub 2017 May 24.
J Biol Chem. 2017.
PMID: 28539360
Free PMC article.
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Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region.
Tetley GJN, Szeto A, Fountain AJ, Mott HR, Owen D.
Tetley GJN, et al.
J Biol Chem. 2018 Sep 28;293(39):15136-15151. doi: 10.1074/jbc.RA118.003290. Epub 2018 Aug 13.
J Biol Chem. 2018.
PMID: 30104412
Free PMC article.
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