Kirchhofer D - Search Results

1

Proprotein convertase 7 (PCSK7) reduces apoA-V levels.

Ashraf Y, Duval S, Sachan V, Essalmani R, Susan-Resiga D, Roubtsova A, Hamelin J, Gerhardy S, Kirchhofer D, Tagliabracci VS, Prat A, Kiss RS, Seidah NG. Ashraf Y, et al. Among authors: kirchhofer d. FEBS J. 2020 Aug;287(16):3565-3578. doi: 10.1111/febs.15212. Epub 2020 Jan 29. FEBS J. 2020. PMID: 31945259 Free article.

2

Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.

Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D. Lipari MT, et al. Among authors: kirchhofer d. J Biol Chem. 2012 Dec 21;287(52):43482-91. doi: 10.1074/jbc.M112.380618. Epub 2012 Nov 7. J Biol Chem. 2012. PMID: 23135270 Free PMC article.

3

Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain.

Ultsch M, Li W, Eigenbrot C, Di Lello P, Lipari MT, Gerhardy S, AhYoung AP, Quinn J, Franke Y, Chen Y, Kong Beltran M, Peterson A, Kirchhofer D. Ultsch M, et al. Among authors: kirchhofer d. J Mol Biol. 2019 Mar 1;431(5):885-903. doi: 10.1016/j.jmb.2018.11.025. Epub 2019 Jan 15. J Mol Biol. 2019. PMID: 30653992

4

An ancient mechanism of arginine-specific substrate cleavage: What's 'up' with NSP4?

AhYoung AP, Lin SJ, Gerhardy S, van Lookeren Campagne M, Kirchhofer D. AhYoung AP, et al. Among authors: kirchhofer d. Biochimie. 2019 Nov;166:19-26. doi: 10.1016/j.biochi.2019.03.020. Epub 2019 Apr 1. Biochimie. 2019. PMID: 30946946 Review.

5

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.

AhYoung AP, Eckard SC, Gogineni A, Xi H, Lin SJ, Gerhardy S, Cox C, Phung QT, Hackney JA, Katakam AK, Reichelt M, Caplazi P, Manzanillo P, Zhang J, Roose-Girma M, Tam LW, Newman RJ, Murthy A, Weimer RM, Lill JR, Lee WP, Grimbaldeston M, Kirchhofer D, van Lookeren Campagne M. AhYoung AP, et al. Among authors: kirchhofer d. Commun Biol. 2020 Nov 19;3(1):687. doi: 10.1038/s42003-020-01407-0. Commun Biol. 2020. PMID: 33214666 Free PMC article.

6

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.

Ultsch M, Holliday MJ, Gerhardy S, Moran P, Scales SJ, Gupta N, Oltrabella F, Chiu C, Fairbrother W, Eigenbrot C, Kirchhofer D. Ultsch M, et al. Among authors: kirchhofer d. Commun Biol. 2021 Jul 27;4(1):916. doi: 10.1038/s42003-021-02387-5. Commun Biol. 2021. PMID: 34316015 Free PMC article.

7

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.

Gerhardy S, Ultsch M, Tang W, Green E, Holden JK, Li W, Estevez A, Arthur C, Tom I, Rohou A, Kirchhofer D. Gerhardy S, et al. Among authors: kirchhofer d. Nat Commun. 2022 Sep 5;13(1):5222. doi: 10.1038/s41467-022-32760-9. Nat Commun. 2022. PMID: 36064790 Free PMC article.

8

Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.

Kirchhofer D, Peek M, Lipari MT, Billeci K, Fan B, Moran P. Kirchhofer D, et al. FEBS Lett. 2005 Mar 28;579(9):1945-50. doi: 10.1016/j.febslet.2005.01.085. FEBS Lett. 2005. PMID: 15792801 Free article.

9

Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).

Eigenbrot C, Ganesan R, Kirchhofer D. Eigenbrot C, et al. Among authors: kirchhofer d. FEBS J. 2010 May;277(10):2215-22. doi: 10.1111/j.1742-4658.2010.07638.x. Epub 2010 Apr 9. FEBS J. 2010. PMID: 20402765 Free article. Review.

10

Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering.

Kirchhofer D, Burdick DJ, Skelton NJ, Zhang Y, Ultsch M. Kirchhofer D, et al. Biochem Soc Trans. 2020 Aug 28;48(4):1323-1336. doi: 10.1042/BST20190672. Biochem Soc Trans. 2020. PMID: 32794575 Review.

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