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Page 1
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
Chianelli D, Rucker PV, Roland J, Tully DC, Nelson J, Liu X, Bursulaya B, Hernandez ED, Wu J, Prashad M, Schlama T, Liu Y, Chu A, Schmeits J, Huang DJ, Hill R, Bao D, Zoll J, Kim Y, Groessl T, McNamara P, Liu B, Richmond W, Sancho-Martinez I, Phimister A, Seidel HM, Badman MK, Joseph SB, Laffitte B, Molteni V. Chianelli D, et al. Among authors: schlama t. J Med Chem. 2020 Apr 23;63(8):3868-3880. doi: 10.1021/acs.jmedchem.9b01621. Epub 2020 Feb 5. J Med Chem. 2020. PMID: 31940200
Application of Transition-Metal Catalysis, Biocatalysis, and Flow Chemistry as State-of-the-Art Technologies in the Synthesis of LCZ696.
Gu X, Zhao J, Chen L, Li Y, Yu B, Tian X, Min Z, Xu S, Gu H, Sun J, Lu X, Chang M, Wang X, Zhao L, Ye S, Yang H, Tian Y, Gao F, Gai Y, Jia G, Wu J, Wang Y, Zhang J, Zhang X, Liu W, Gu X, Luo X, Dong H, Wang H, Schenkel B, Venturoni F, Filipponi P, Guelat B, Allmendinger T, Wietfeld B, Hoehn P, Kovacic N, Hermann L, Schlama T, Ruch T, Derrien N, Piechon P, Kleinbeck F. Gu X, et al. Among authors: schlama t. J Org Chem. 2020 Jun 5;85(11):6844-6853. doi: 10.1021/acs.joc.0c00473. Epub 2020 May 15. J Org Chem. 2020. PMID: 32412751
Fostering Research Synergies between Chemists in Swiss Academia and at Novartis.
Meyer A, Baeschlin D, Brocklehurst CE, Duckely M, Gallou F, Lovelle LE, Parmentier M, Schlama T, Snajdrova R, Auberson YP. Meyer A, et al. Among authors: schlama t. Chimia (Aarau). 2021 Nov 24;75(11):936-942. doi: 10.2533/chimia.2021.936. Chimia (Aarau). 2021. PMID: 34798915 Free article.
Total Synthesis of (±)-Halomon by a Johnson-Claisen Rearrangement.
Schlama T, Baati R, Gouverneur V, Valleix A, Falck JR, Mioskowski C. Schlama T, et al. Angew Chem Int Ed Engl. 1998 Aug 17;37(15):2085-2087. doi: 10.1002/(SICI)1521-3773(19980817)37:15<2085::AID-ANIE2085>3.0.CO;2-J. Angew Chem Int Ed Engl. 1998. PMID: 29711050
Evolution of Biocatalysis at Novartis over the last 40 Years.
Siirola E, Eggimann F, Moore C, Schroer K, Vargas A, Peschke T, Schlama T, Snajdrova R. Siirola E, et al. Among authors: schlama t. Chimia (Aarau). 2023 Jun 28;77(6):376-383. doi: 10.2533/chimia.2023.376. Chimia (Aarau). 2023. PMID: 38047776 Free article.