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High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.
Abelein A, Chen G, Kitoka K, Aleksis R, Oleskovs F, Sarr M, Landreh M, Pahnke J, Nordling K, Kronqvist N, Jaudzems K, Rising A, Johansson J, Biverstål H. Abelein A, et al. Among authors: biverstal h. Sci Rep. 2020 Jan 14;10(1):235. doi: 10.1038/s41598-019-57143-x. Sci Rep. 2020. PMID: 31937841 Free PMC article.
BRICHOS domains efficiently delay fibrillation of amyloid β-peptide.
Willander H, Presto J, Askarieh G, Biverstål H, Frohm B, Knight SD, Johansson J, Linse S. Willander H, et al. Among authors: biverstal h. J Biol Chem. 2012 Sep 7;287(37):31608-17. doi: 10.1074/jbc.M112.393157. Epub 2012 Jul 16. J Biol Chem. 2012. PMID: 22801430 Free PMC article.
Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation.
Kurudenkandy FR, Zilberter M, Biverstål H, Presto J, Honcharenko D, Strömberg R, Johansson J, Winblad B, Fisahn A. Kurudenkandy FR, et al. Among authors: biverstal h. J Neurosci. 2014 Aug 20;34(34):11416-25. doi: 10.1523/JNEUROSCI.1195-14.2014. J Neurosci. 2014. PMID: 25143621 Free PMC article.
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
Cohen SIA, Arosio P, Presto J, Kurudenkandy FR, Biverstal H, Dolfe L, Dunning C, Yang X, Frohm B, Vendruscolo M, Johansson J, Dobson CM, Fisahn A, Knowles TPJ, Linse S. Cohen SIA, et al. Among authors: biverstal h. Nat Struct Mol Biol. 2015 Mar;22(3):207-213. doi: 10.1038/nsmb.2971. Epub 2015 Feb 16. Nat Struct Mol Biol. 2015. PMID: 25686087 Free PMC article.
Efficient protein production inspired by how spiders make silk.
Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, Pioselli B, Purhonen P, Landreh M, Biverstål H, Toleikis Z, Sjöberg L, Robinson CV, Pelizzi N, Jörnvall H, Hebert H, Jaudzems K, Curstedt T, Rising A, Johansson J. Kronqvist N, et al. Among authors: biverstal h. Nat Commun. 2017 May 23;8:15504. doi: 10.1038/ncomms15504. Nat Commun. 2017. PMID: 28534479 Free PMC article.
31 results