Jenner RG - Search Results

1

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

Śledzińska A, Vila de Mucha M, Bergerhoff K, Hotblack A, Demane DF, Ghorani E, Akarca AU, Marzolini MAV, Solomon I, Vargas FA, Pule M, Ono M, Seddon B, Kassiotis G, Ariyan CE, Korn T, Marafioti T, Lord GM, Stauss H, Jenner RG, Peggs KS, Quezada SA. Śledzińska A, et al. Among authors: jenner rg. Immunity. 2020 Jan 14;52(1):151-166.e6. doi: 10.1016/j.immuni.2019.12.007. Epub 2020 Jan 7. Immunity. 2020. PMID: 31924474 Free PMC article.

2

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

Powell N, Walker AW, Stolarczyk E, Canavan JB, Gökmen MR, Marks E, Jackson I, Hashim A, Curtis MA, Jenner RG, Howard JK, Parkhill J, MacDonald TT, Lord GM. Powell N, et al. Among authors: jenner rg. Immunity. 2012 Oct 19;37(4):674-84. doi: 10.1016/j.immuni.2012.09.008. Epub 2012 Oct 11. Immunity. 2012. PMID: 23063332 Free PMC article.

3

The TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes.

Hertweck A, Vila de Mucha M, Barber PR, Dagil R, Porter H, Ramos A, Lord GM, Jenner RG. Hertweck A, et al. Among authors: jenner rg. Nucleic Acids Res. 2022 May 6;50(8):4557-4573. doi: 10.1093/nar/gkac258. Nucleic Acids Res. 2022. PMID: 35438764 Free PMC article.

4

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.

Kanhere A, Hertweck A, Bhatia U, Gökmen MR, Perucha E, Jackson I, Lord GM, Jenner RG. Kanhere A, et al. Among authors: jenner rg. Nat Commun. 2012;3:1268. doi: 10.1038/ncomms2260. Nat Commun. 2012. PMID: 23232398 Free PMC article.

5

Exhausted CD4⁺ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression.

Villegas-Mendez A, Khandelwal G, McGowan LM, Dookie RS, Haley MJ, George C, Sims D, Lord GM, Sinclair LV, Jenner RG, Couper KN. Villegas-Mendez A, et al. Among authors: jenner rg. J Immunol. 2020 Sep 15;205(6):1608-1619. doi: 10.4049/jimmunol.2000450. Epub 2020 Aug 17. J Immunol. 2020. PMID: 32817333 Free PMC article.

6

The Th1 cell regulatory circuitry is largely conserved between human and mouse.

Henderson S, Pullabhatla V, Hertweck A, de Rinaldis E, Herrero J, Lord GM, Jenner RG. Henderson S, et al. Among authors: jenner rg. Life Sci Alliance. 2021 Sep 16;4(11):e202101075. doi: 10.26508/lsa.202101075. Print 2021 Nov. Life Sci Alliance. 2021. PMID: 34531288 Free PMC article.

7

A population of naive-like CD4⁺ T cells stably polarized to the T_H 1 lineage.

Lo JW, de Mucha MV, Henderson S, Roberts LB, Constable LE, Garrido-Mesa N, Hertweck A, Stolarczyk E, Houlder EL, Jackson I, MacDonald AS, Powell N, Neves JF, Howard JK, Jenner RG, Lord GM. Lo JW, et al. Among authors: jenner rg. Eur J Immunol. 2022 Apr;52(4):566-581. doi: 10.1002/eji.202149228. Epub 2022 Feb 12. Eur J Immunol. 2022. PMID: 35092032 Free PMC article.

8

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.

Jenner RG, Townsend MJ, Jackson I, Sun K, Bouwman RD, Young RA, Glimcher LH, Lord GM. Jenner RG, et al. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17876-81. doi: 10.1073/pnas.0909357106. Epub 2009 Oct 5. Proc Natl Acad Sci U S A. 2009. PMID: 19805038 Free PMC article.

9

Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4.

Gökmen MR, Dong R, Kanhere A, Powell N, Perucha E, Jackson I, Howard JK, Hernandez-Fuentes M, Jenner RG, Lord GM. Gökmen MR, et al. Among authors: jenner rg. J Immunol. 2013 Dec 15;191(12):5925-32. doi: 10.4049/jimmunol.1202254. Epub 2013 Nov 18. J Immunol. 2013. PMID: 24249732 Free PMC article.

10

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

Soderquest K, Hertweck A, Giambartolomei C, Henderson S, Mohamed R, Goldberg R, Perucha E, Franke L, Herrero J, Plagnol V, Jenner RG, Lord GM. Soderquest K, et al. Among authors: jenner rg. PLoS Genet. 2017 Feb 10;13(2):e1006587. doi: 10.1371/journal.pgen.1006587. eCollection 2017 Feb. PLoS Genet. 2017. PMID: 28187197 Free PMC article.

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