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Parkinson's disease: proteinopathy or lipidopathy?
Fanning S, Selkoe D, Dettmer U. Fanning S, et al. NPJ Parkinsons Dis. 2020 Jan 3;6:3. doi: 10.1038/s41531-019-0103-7. eCollection 2020. NPJ Parkinsons Dis. 2020. PMID: 31909184 Free PMC article. Review.
[No title available]
[No authors listed] [No authors listed] PMID: 33386391
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Dettmer U, et al. Among authors: fanning s. Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227. Hum Mol Genet. 2017. PMID: 28911198 Free PMC article.
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Fanning S, et al. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. Mol Cell. 2019. PMID: 30527540 Free PMC article.
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Imberdis T, et al. Among authors: fanning s. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20760-20769. doi: 10.1073/pnas.1903216116. Epub 2019 Sep 23. Proc Natl Acad Sci U S A. 2019. PMID: 31548371 Free PMC article.
Vesicle trafficking and lipid metabolism in synucleinopathy.
Fanning S, Selkoe D, Dettmer U. Fanning S, et al. Acta Neuropathol. 2021 Apr;141(4):491-510. doi: 10.1007/s00401-020-02177-z. Epub 2020 Jun 30. Acta Neuropathol. 2021. PMID: 32607605 Free PMC article. Review.
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, Selkoe DJ. Nuber S, et al. Among authors: fanning s. Ann Neurol. 2021 Jan;89(1):74-90. doi: 10.1002/ana.25920. Epub 2020 Oct 23. Ann Neurol. 2021. PMID: 32996158 Free PMC article.
545 results