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3-((R)-4-(((R)-6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4.
Ren Q, Liu X, Yan G, Nie B, Zou Z, Li J, Chen Y, Wei Y, Huang J, Luo Z, Gu B, Goldmann S, Zhang J, Zhang Y. Ren Q, et al. J Med Chem. 2018 Feb 8;61(3):1355-1374. doi: 10.1021/acs.jmedchem.7b01914. Epub 2018 Jan 30. J Med Chem. 2018. PMID: 29381358
Efficacy and Safety of All-oral Emitasvir and Sofosbuvir in Patients with Genotype 1b HCV Infections without Cirrhosis.
Rao H, Yang X, Tan Y, Ning Q, Yang D, Wang J, Yang Y, Zheng S, Yang D, Hou J, Xie Q, Zhao C, Zhang L, Mao X, Sun T, Bai L, Zhang F, Jin J, Zhao Y, Wang M, Xie W, Ma Y, Quan J, Yan X, An P, Lin F, Jia J, Hu X, Gong Z, Wu J, Chen Y, Jia Z, Lin M, Wang G, Zhu Y, Zhang Y, Xie H, Luo L, Ren Q, Huang R, Wei L. Rao H, et al. Among authors: ren q. J Clin Transl Hepatol. 2020 Sep 28;8(3):255-261. doi: 10.14218/JCTH.2020.00031. Epub 2020 Sep 11. J Clin Transl Hepatol. 2020. PMID: 33083247 Free PMC article.
A First-in-Human Trial of GLS4, a Novel Inhibitor of Hepatitis B Virus Capsid Assembly, following Single- and Multiple-Ascending-Oral-Dose Studies with or without Ritonavir in Healthy Adult Volunteers.
Zhao N, Jia B, Zhao H, Xu J, Sheng X, Luo L, Huang Z, Wang X, Ren Q, Zhang Y, Zhao X, Cui Y. Zhao N, et al. Among authors: ren q. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01686-19. doi: 10.1128/AAC.01686-19. Print 2019 Dec 20. Antimicrob Agents Chemother. 2019. PMID: 31636065 Free PMC article. Clinical Trial.
3,026 results