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Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.
Perković I, Raić-Malić S, Fontinha D, Prudêncio M, Pessanha de Carvalho L, Held J, Tandarić T, Vianello R, Zorc B, Rajić Z. Perković I, et al. Among authors: held j. Eur J Med Chem. 2020 Feb 1;187:111927. doi: 10.1016/j.ejmech.2019.111927. Epub 2019 Nov 29. Eur J Med Chem. 2020. PMID: 31812035
Novel Harmicines with Improved Potency against Plasmodium.
Marinović M, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Zorc B, Rajić Z. Marinović M, et al. Among authors: held j. Molecules. 2020 Sep 23;25(19):4376. doi: 10.3390/molecules25194376. Molecules. 2020. PMID: 32977642 Free PMC article.
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum.
Knaab TC, Held J, Burckhardt BB, Rubiano K, Okombo J, Yeo T, Mok S, Uhlemann AC, Lungerich B, Fischli C, Pessanha de Carvalho L, Mordmüller B, Wittlin S, Fidock DA, Kurz T. Knaab TC, et al. Among authors: held j. J Med Chem. 2021 Mar 25;64(6):3035-3047. doi: 10.1021/acs.jmedchem.0c01744. Epub 2021 Mar 5. J Med Chem. 2021. PMID: 33666415 Free PMC article.
Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
Ekoka Mbassi D, Mombo-Ngoma G, Held J, Okwu DG, Ndzebe-Ndoumba W, Kalkman LC, Ekoka Mbassi FA, Pessanha de Carvalho L, Inoue J, Akinosho MA, Dimessa Mbadinga LB, Yovo EK, Mordmüller B, Kremsner PG, Adegnika AA, Ramharter M, Zoleko-Manego R. Ekoka Mbassi D, et al. Among authors: held j. EBioMedicine. 2023 Nov;97:104814. doi: 10.1016/j.ebiom.2023.104814. Epub 2023 Oct 13. EBioMedicine. 2023. PMID: 37839134 Free PMC article. Clinical Trial.
625 results