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Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.
Zagórska A, Bucki A, Partyka A, Jastrzębska-Więsek M, Siwek A, Głuch-Lutwin M, Mordyl B, Jaromin A, Walczak M, Wesołowska A, Kołaczkowski M. Zagórska A, et al. Eur J Med Chem. 2022 Apr 5;233:114218. doi: 10.1016/j.ejmech.2022.114218. Epub 2022 Feb 25. Eur J Med Chem. 2022. PMID: 35248836
Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.
Zagórska A, Bucki A, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Starowicz G, Kazek G, Partyka A, Wesołowska A, Słoczyńska K, Pękala E, Pawłowski M. Zagórska A, et al. J Enzyme Inhib Med Chem. 2016;31(sup3):10-24. doi: 10.1080/14756366.2016.1198902. Epub 2016 Jun 29. J Enzyme Inhib Med Chem. 2016. PMID: 27353547
Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A /5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity.
Chłoń-Rzepa G, Zagórska A, Żmudzki P, Bucki A, Kołaczkowski M, Partyka A, Wesołowska A, Kazek G, Głuch-Lutwin M, Siwek A, Starowicz G, Pawłowski M. Chłoń-Rzepa G, et al. Among authors: zagorska a. Arch Pharm (Weinheim). 2016 Dec;349(12):889-903. doi: 10.1002/ardp.201600260. Epub 2016 Nov 21. Arch Pharm (Weinheim). 2016. PMID: 27869315
Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl-piperazinyl-alkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione with antidepressant- and anxiolytic-like activities.
Zagórska A, Partyka A, Bucki A, Kołaczkowski M, Jastrzębska-Więsek M, Czopek A, Siwek A, Głuch-Lutwin M, Bednarski M, Bajda M, Jończyk J, Piska K, Koczurkiewicz P, Wesołowska A, Pawłowski M. Zagórska A, et al. Chem Biol Drug Des. 2019 Apr;93(4):511-521. doi: 10.1111/cbdd.13442. Epub 2018 Dec 4. Chem Biol Drug Des. 2019. PMID: 30422400
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.
Czopek A, Partyka A, Bucki A, Pawłowski M, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Koczurkiewicz P, Pękala E, Jaromin A, Tyliszczak B, Wesołowska A, Zagórska A. Czopek A, et al. Among authors: zagorska a. Molecules. 2020 Aug 25;25(17):3868. doi: 10.3390/molecules25173868. Molecules. 2020. PMID: 32854402 Free PMC article.
The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
Jastrzębska-Więsek M, Kotańska M, Grzeszczak A, Jaromin A, Walczak M, Partyka A, Gdula-Argasińska J, Smolik M, Zagórska A. Jastrzębska-Więsek M, et al. Among authors: zagorska a. Int J Mol Sci. 2022 Sep 28;23(19):11452. doi: 10.3390/ijms231911452. Int J Mol Sci. 2022. PMID: 36232749 Free PMC article.
87 results