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Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response.
Wei X, Shao B, He Z, Ye T, Luo M, Sang Y, Liang X, Wang W, Luo S, Yang S, Zhang S, Gong C, Gou M, Deng H, Zhao Y, Yang H, Deng S, Zhao C, Yang L, Qian Z, Li J, Sun X, Han J, Jiang C, Wu M, Zhang Z. Wei X, et al. Among authors: yang s, yang l, yang h. Cell Res. 2015 Feb;25(2):237-53. doi: 10.1038/cr.2015.9. Epub 2015 Jan 23. Cell Res. 2015. PMID: 25613571 Free PMC article.
From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer.
Zhang CH, Chen K, Jiao Y, Li LL, Li YP, Zhang RJ, Zheng MW, Zhong L, Huang SZ, Song CL, Lin WT, Yang J, Xiang R, Peng B, Han JH, Lu GW, Wei YQ, Yang SY. Zhang CH, et al. J Med Chem. 2016 Nov 10;59(21):9788-9805. doi: 10.1021/acs.jmedchem.6b00943. Epub 2016 Oct 26. J Med Chem. 2016. PMID: 27739679
Malignant Pleural Effusion and ascites Induce Epithelial-Mesenchymal Transition and Cancer Stem-like Cell Properties via the Vascular Endothelial Growth Factor (VEGF)/Phosphatidylinositol 3-Kinase (PI3K)/Akt/Mechanistic Target of Rapamycin (mTOR) Pathway.
Yin T, Wang G, He S, Shen G, Su C, Zhang Y, Wei X, Ye T, Li L, Yang S, Li D, Guo F, Mo Z, Wan Y, Ai P, Zhou X, Liu Y, Wang Y, Wei Y. Yin T, et al. Among authors: yang s. J Biol Chem. 2016 Dec 23;291(52):26750-26761. doi: 10.1074/jbc.M116.753236. Epub 2016 Oct 18. J Biol Chem. 2016. PMID: 27756837 Free PMC article.
Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.
Sun Q, Hu Y, Gu Y, Huang J, He J, Luo L, Yang Y, Yin S, Dou C, Wang T, Fu X, He L, Qi S, Zhu X, Yang S, Wei X, Cheng W. Sun Q, et al. Among authors: yang s, yang y. Signal Transduct Target Ther. 2019 May 24;4:17. doi: 10.1038/s41392-019-0052-y. eCollection 2019. Signal Transduct Target Ther. 2019. PMID: 31149354 Free PMC article.
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