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Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
Elife. 2019 Dec 23;8:e50163. doi: 10.7554/eLife.50163.
Elife. 2019.
PMID: 31868166
Free PMC article.
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration.
Aharonov A, Shakked A, Umansky KB, Savidor A, Genzelinakh A, Kain D, Lendengolts D, Revach OY, Morikawa Y, Dong J, Levin Y, Geiger B, Martin JF, Tzahor E.
Aharonov A, et al. Among authors: shakked a.
Nat Cell Biol. 2020 Nov;22(11):1346-1356. doi: 10.1038/s41556-020-00588-4. Epub 2020 Oct 12.
Nat Cell Biol. 2020.
PMID: 33046882
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Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues.
Kastan N, Gnedeva K, Alisch T, Petelski AA, Huggins DJ, Chiaravalli J, Aharanov A, Shakked A, Tzahor E, Nagiel A, Segil N, Hudspeth AJ.
Kastan N, et al. Among authors: shakked a.
Nat Commun. 2021 May 25;12(1):3100. doi: 10.1038/s41467-021-23395-3.
Nat Commun. 2021.
PMID: 34035288
Free PMC article.
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ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.
Eigler T, Zarfati G, Amzallag E, Sinha S, Segev N, Zabary Y, Zaritsky A, Shakked A, Umansky KB, Schejter ED, Millay DP, Tzahor E, Avinoam O.
Eigler T, et al. Among authors: shakked a.
Dev Cell. 2021 Dec 20;56(24):3349-3363.e6. doi: 10.1016/j.devcel.2021.11.022.
Dev Cell. 2021.
PMID: 34932950
Free PMC article.
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Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury.
Shakked A, Petrover Z, Aharonov A, Ghiringhelli M, Umansky KB, Kain D, Elkahal J, Divinsky Y, Nguyen PD, Miyara S, Friedlander G, Savidor A, Zhang L, Perez DE, Sarig R, Lendengolts D, Bueno-Levy H, Kastan N, Levin Y, Bakkers J, Gepstein L, Tzahor E.
Shakked A, et al.
Nat Cardiovasc Res. 2023 Apr;2(4):383-398. doi: 10.1038/s44161-023-00250-w. Epub 2023 Mar 8.
Nat Cardiovasc Res. 2023.
PMID: 37974970
Free PMC article.
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Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration.
Nguyen PD, Gooijers I, Campostrini G, Verkerk AO, Honkoop H, Bouwman M, de Bakker DEM, Koopmans T, Vink A, Lamers GEM, Shakked A, Mars J, Mulder AA, Chocron S, Bartscherer K, Tzahor E, Mummery CL, de Boer TP, Bellin M, Bakkers J.
Nguyen PD, et al. Among authors: shakked a.
Science. 2023 May 19;380(6646):758-764. doi: 10.1126/science.abo6718. Epub 2023 May 18.
Science. 2023.
PMID: 37200435
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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD.
Yan R, et al. Among authors: shakked a.
Cell Stem Cell. 2023 Jan 5;30(1):96-111.e6. doi: 10.1016/j.stem.2022.11.012. Epub 2022 Dec 13.
Cell Stem Cell. 2023.
PMID: 36516837
Free PMC article.
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