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Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM. Dawidowski M, et al. Among authors: dubin g. J Med Chem. 2020 Jan 23;63(2):847-879. doi: 10.1021/acs.jmedchem.9b01876. Epub 2020 Jan 6. J Med Chem. 2020. PMID: 31860309
Enzymatic activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln.
Dubin G, Stec-Niemczyk J, Kisielewska M, Pustelny K, Popowicz GM, Bista M, Kantyka T, Boulware KT, Stennicke HR, Czarna A, Phopaisarn M, Daugherty PS, Thøgersen IB, Enghild JJ, Thornberry N, Dubin A, Potempa J. Dubin G, et al. Among authors: dubin a. J Mol Biol. 2008 May 30;379(2):343-56. doi: 10.1016/j.jmb.2008.03.059. Epub 2008 Apr 3. J Mol Biol. 2008. PMID: 18448121
Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation.
Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G. Pustelny K, et al. Among authors: dubin g, dubin a. J Biol Chem. 2014 May 30;289(22):15544-53. doi: 10.1074/jbc.M113.507616. Epub 2014 Apr 8. J Biol Chem. 2014. PMID: 24713703 Free PMC article.
210 results