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Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
Klossowski S, Miao H, Kempinska K, Wu T, Purohit T, Kim E, Linhares BM, Chen D, Jih G, Perkey E, Huang H, He M, Wen B, Wang Y, Yu K, Lee SC, Danet-Desnoyers G, Trotman W, Kandarpa M, Cotton A, Abdel-Wahab O, Lei H, Dou Y, Guzman M, Peterson L, Gruber T, Choi S, Sun D, Ren P, Li LS, Liu Y, Burrows F, Maillard I, Cierpicki T, Grembecka J. Klossowski S, et al. Among authors: dou y. J Clin Invest. 2020 Feb 3;130(2):981-997. doi: 10.1172/JCI129126. J Clin Invest. 2020. PMID: 31855575 Free PMC article.
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.
Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, Dou Y, Schnepp RW, Krankel C, Livolsi VA, Gibbs D, Hua X, Roeder RG, Meyerson M, Hess JL. Milne TA, et al. Among authors: dou y. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):749-54. doi: 10.1073/pnas.0408836102. Epub 2005 Jan 7. Proc Natl Acad Sci U S A. 2005. PMID: 15640349 Free PMC article.
Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Cao F, Townsend EC, Karatas H, Xu J, Li L, Lee S, Liu L, Chen Y, Ouillette P, Zhu J, Hess JL, Atadja P, Lei M, Qin ZS, Malek S, Wang S, Dou Y. Cao F, et al. Among authors: dou y. Mol Cell. 2014 Jan 23;53(2):247-61. doi: 10.1016/j.molcel.2013.12.001. Epub 2014 Jan 2. Mol Cell. 2014. PMID: 24389101 Free PMC article.
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.
Jones M, Chase J, Brinkmeier M, Xu J, Weinberg DN, Schira J, Friedman A, Malek S, Grembecka J, Cierpicki T, Dou Y, Camper SA, Maillard I. Jones M, et al. Among authors: dou y. J Clin Invest. 2015 May;125(5):2007-20. doi: 10.1172/JCI78124. Epub 2015 Apr 13. J Clin Invest. 2015. PMID: 25866973 Free PMC article.
Epigenetic regulation of IL-12-dependent T cell proliferation.
Schaller M, Ito T, Allen RM, Kroetz D, Kittan N, Ptaschinski C, Cavassani K, Carson WF 4th, Godessart N, Grembecka J, Cierpicki T, Dou Y, Kunkel SL. Schaller M, et al. Among authors: dou y. J Leukoc Biol. 2015 Oct;98(4):601-13. doi: 10.1189/jlb.1A0814-375RR. Epub 2015 Jun 9. J Leukoc Biol. 2015. PMID: 26059830 Free PMC article.
Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.
Bai L, Zhou B, Yang CY, Ji J, McEachern D, Przybranowski S, Jiang H, Hu J, Xu F, Zhao Y, Liu L, Fernandez-Salas E, Xu J, Dou Y, Wen B, Sun D, Meagher J, Stuckey J, Hayes DF, Li S, Ellis MJ, Wang S. Bai L, et al. Among authors: dou y. Cancer Res. 2017 May 1;77(9):2476-2487. doi: 10.1158/0008-5472.CAN-16-2622. Epub 2017 Feb 16. Cancer Res. 2017. PMID: 28209615 Free PMC article.
1,865 results