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Metabolic heterogeneity confers differences in melanoma metastatic potential.
Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ, Morrison SJ. Tasdogan A, et al. Among authors: gu w, gu z. Nature. 2020 Jan;577(7788):115-120. doi: 10.1038/s41586-019-1847-2. Epub 2019 Dec 18. Nature. 2020. PMID: 31853067 Free PMC article.
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ. Huang F, et al. Among authors: gu w. Cell Metab. 2018 Sep 4;28(3):369-382.e5. doi: 10.1016/j.cmet.2018.06.005. Epub 2018 Jun 28. Cell Metab. 2018. PMID: 30043754 Free PMC article.
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJ. Kim J, et al. Among authors: gu w. Nat Metab. 2020 Dec;2(12):1401-1412. doi: 10.1038/s42255-020-00316-0. Epub 2020 Nov 30. Nat Metab. 2020. PMID: 33257855 Free PMC article.
Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells.
Aurora AB, Khivansara V, Leach A, Gill JG, Martin-Sandoval M, Yang C, Kasitinon SY, Bezwada D, Tasdogan A, Gu W, Mathews TP, Zhao Z, DeBerardinis RJ, Morrison SJ. Aurora AB, et al. Among authors: gu w. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2120617119. doi: 10.1073/pnas.2120617119. Proc Natl Acad Sci U S A. 2022. PMID: 35110412 Free PMC article.
Compartmentalized metabolism supports midgestation mammalian development.
Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA, Morrison SJ, DeBerardinis RJ. Solmonson A, et al. Among authors: gu w. Nature. 2022 Apr;604(7905):349-353. doi: 10.1038/s41586-022-04557-9. Epub 2022 Apr 6. Nature. 2022. PMID: 35388219 Free PMC article.
In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors.
Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, Solmonson A, Rao AD, Kaushik AK, Rogers TJ, Ubellacker JM, LaVigne CA, Yang C, Ko B, Ramesh V, Sudderth J, Zacharias LG, Martin-Sandoval MS, Do D, Mathews TP, Zhao Z, Mishra P, Morrison SJ, DeBerardinis RJ. Pachnis P, et al. Among authors: gu w. Sci Adv. 2022 Sep 2;8(35):eabn9550. doi: 10.1126/sciadv.abn9550. Epub 2022 Aug 31. Sci Adv. 2022. PMID: 36044570 Free PMC article.
Electron transport chain inhibition increases cellular dependence on purine transport and salvage.
Wu Z, Bezwada D, Harris RC, Pan C, Nguyen PT, Faubert B, Cai L, Cai F, Vu HS, Chen H, Sandoval MM, Do D, Gu W, Zhang Y, Ko B, Brooks B, Kelekar S, Zhang Y, Zacharias LG, Oaxaca KC, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ. Wu Z, et al. Among authors: gu w. bioRxiv [Preprint]. 2023 May 11:2023.05.11.540429. doi: 10.1101/2023.05.11.540429. bioRxiv. 2023. PMID: 37214913 Free PMC article. Preprint.
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples.
Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang MC, Pachnis P, Yang C, Kelekar S, Gu W, Brooks B, Ko B, Vu HS, Mathews TP, Zacharias LG, Martin-Sandoval M, Do D, Oaxaca KC, Jin ES, Margulis V, Malloy CR, Merritt ME, DeBerardinis RJ. Cai F, et al. Among authors: gu w. Cell Metab. 2023 Oct 3;35(10):1830-1843.e5. doi: 10.1016/j.cmet.2023.07.013. Epub 2023 Aug 22. Cell Metab. 2023. PMID: 37611583 Free PMC article.
5,757 results