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Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene.
Chumarina M, Russ K, Azevedo C, Heuer A, Pihl M, Collin A, Frostner EÅ, Elmer E, Hyttel P, Cappelletti G, Zini M, Goldwurm S, Roybon L. Chumarina M, et al. Among authors: cappelletti g. Acta Neuropathol Commun. 2019 Dec 16;7(1):208. doi: 10.1186/s40478-019-0863-7. Acta Neuropathol Commun. 2019. PMID: 31843010 Free PMC article.
α-Synuclein is a Novel Microtubule Dynamase.
Cartelli D, Aliverti A, Barbiroli A, Santambrogio C, Ragg EM, Casagrande FV, Cantele F, Beltramone S, Marangon J, De Gregorio C, Pandini V, Emanuele M, Chieregatti E, Pieraccini S, Holmqvist S, Bubacco L, Roybon L, Pezzoli G, Grandori R, Arnal I, Cappelletti G. Cartelli D, et al. Among authors: cappelletti g. Sci Rep. 2016 Sep 15;6:33289. doi: 10.1038/srep33289. Sci Rep. 2016. PMID: 27628239 Free PMC article.
Parkin absence accelerates microtubule aging in dopaminergic neurons.
Cartelli D, Amadeo A, Calogero AM, Casagrande FVM, De Gregorio C, Gioria M, Kuzumaki N, Costa I, Sassone J, Ciammola A, Hattori N, Okano H, Goldwurm S, Roybon L, Pezzoli G, Cappelletti G. Cartelli D, et al. Among authors: cappelletti g. Neurobiol Aging. 2018 Jan;61:66-74. doi: 10.1016/j.neurobiolaging.2017.09.010. Epub 2017 Sep 20. Neurobiol Aging. 2018. PMID: 29040870
Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism.
Baden P, Perez MJ, Raji H, Bertoli F, Kalb S, Illescas M, Spanos F, Giuliano C, Calogero AM, Oldrati M, Hebestreit H, Cappelletti G, Brockmann K, Gasser T, Schapira AHV, Ugalde C, Deleidi M. Baden P, et al. Among authors: cappelletti g. Nat Commun. 2023 Apr 6;14(1):1930. doi: 10.1038/s41467-023-37454-4. Nat Commun. 2023. PMID: 37024507 Free PMC article.
Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M, Chieregatti E, Mulle C, Passafaro M, Sassone J. Maraschi A, et al. Among authors: cappelletti g. Nat Commun. 2014 Oct 15;5:5182. doi: 10.1038/ncomms6182. Nat Commun. 2014. PMID: 25316086 Free PMC article.
162 results