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Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.
Webster MR, Fane ME, Alicea GM, Basu S, Kossenkov AV, Marino GE, Douglass SM, Kaur A, Ecker BL, Gnanapradeepan K, Ndoye A, Kugel C, Valiga A, Palmer J, Liu Q, Xu X, Morris J, Yin X, Wu H, Xu W, Zheng C, Karakousis GC, Amaravadi RK, Mitchell TC, Almeida FV, Xiao M, Rebecca VW, Wang YJ, Schuchter LM, Herlyn M, Murphy ME, Weeraratna AT. Webster MR, et al. Among authors: murphy me. Mol Cell. 2020 Feb 6;77(3):633-644.e5. doi: 10.1016/j.molcel.2019.11.009. Epub 2019 Dec 11. Mol Cell. 2020. PMID: 31836388 Free PMC article.
A modified HSP70 inhibitor shows broad activity as an anticancer agent.
Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL Jr, Yen T, George DL, Murphy ME. Balaburski GM, et al. Among authors: murphy me. Mol Cancer Res. 2013 Mar;11(3):219-29. doi: 10.1158/1541-7786.MCR-12-0547-T. Epub 2013 Jan 9. Mol Cancer Res. 2013. PMID: 23303345 Free PMC article.
Autophagy researchers.
Amaravadi R, Murphy ME, Soldati T, Vindis C. Amaravadi R, et al. Among authors: murphy me. Autophagy. 2014 May;10(5):717-20. doi: 10.4161/auto.28362. Epub 2014 Mar 26. Autophagy. 2014. PMID: 24686294 Free PMC article. No abstract available.
Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
Webster MR, Xu M, Kinzler KA, Kaur A, Appleton J, O'Connell MP, Marchbank K, Valiga A, Dang VM, Perego M, Zhang G, Slipicevic A, Keeney F, Lehrmann E, Wood W 3rd, Becker KG, Kossenkov AV, Frederick DT, Flaherty KT, Xu X, Herlyn M, Murphy ME, Weeraratna AT. Webster MR, et al. Among authors: murphy me. Pigment Cell Melanoma Res. 2015 Mar;28(2):184-95. doi: 10.1111/pcmr.12330. Epub 2014 Dec 29. Pigment Cell Melanoma Res. 2015. PMID: 25407936 Free PMC article.
HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.
Budina-Kolomets A, Webster MR, Leu JI, Jennis M, Krepler C, Guerrini A, Kossenkov AV, Xu W, Karakousis G, Schuchter L, Amaravadi RK, Wu H, Yin X, Liu Q, Lu Y, Mills GB, Xu X, George DL, Weeraratna AT, Murphy ME. Budina-Kolomets A, et al. Among authors: murphy me. Cancer Res. 2016 May 1;76(9):2720-30. doi: 10.1158/0008-5472.CAN-15-2137. Epub 2016 Mar 16. Cancer Res. 2016. PMID: 26984758 Free PMC article.
An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.
Jennis M, Kung CP, Basu S, Budina-Kolomets A, Leu JI, Khaku S, Scott JP, Cai KQ, Campbell MR, Porter DK, Wang X, Bell DA, Li X, Garlick DS, Liu Q, Hollstein M, George DL, Murphy ME. Jennis M, et al. Among authors: murphy me. Genes Dev. 2016 Apr 15;30(8):918-30. doi: 10.1101/gad.275891.115. Epub 2016 Mar 31. Genes Dev. 2016. PMID: 27034505 Free PMC article.
439 results