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Crystal Structure of Human CD47 in Complex with Engineered SIRPα.D1(N80A).
Yu J, Li S, Chen D, Liu D, Guo H, Yang C, Zhang W, Zhang L, Zhao G, Tu X, Peng L, Liu S, Bai X, Song Y, Jiang Z, Zhang R, Tian W. Yu J, et al. Among authors: tian w. Molecules. 2022 Aug 30;27(17):5574. doi: 10.3390/molecules27175574. Molecules. 2022. PMID: 36080360 Free PMC article.
SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the "don't eat me" signal and activating the "eat me" signal.
Yu J, Li S, Chen D, Liu D, Guo H, Yang C, Zhang W, Zhang L, Zhao G, Tu X, Peng L, Liu S, Bai X, Song Y, Jiang Z, Zhang R, Tian W. Yu J, et al. Among authors: tian w. J Hematol Oncol. 2022 Nov 16;15(1):167. doi: 10.1186/s13045-022-01385-2. J Hematol Oncol. 2022. PMID: 36384978 Free PMC article.
IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells.
Yu J, Li S, Chen D, Liu D, Guo H, Yang C, Zhang W, Zhang L, Zhao G, Tu X, Peng L, Liu S, Bai X, Song Y, Jiang Z, Zhang R, Tian W. Yu J, et al. Among authors: tian w. Leukemia. 2023 Mar;37(3):695-698. doi: 10.1038/s41375-022-01805-9. Epub 2022 Dec 27. Leukemia. 2023. PMID: 36575242 Free PMC article. No abstract available.
5,015 results