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284 results

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Circulating Growth Differentiation Factor 11/8 Levels Decline With Age.
Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT. Poggioli T, et al. Among authors: walker rg. Circ Res. 2016 Jan 8;118(1):29-37. doi: 10.1161/CIRCRESAHA.115.307521. Epub 2015 Oct 21. Circ Res. 2016. PMID: 26489925 Free PMC article.
Structural basis for potency differences between GDF8 and GDF11.
Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB. Walker RG, et al. BMC Biol. 2017 Mar 3;15(1):19. doi: 10.1186/s12915-017-0350-1. BMC Biol. 2017. PMID: 28257634 Free PMC article.
Molecular characterization of latent GDF8 reveals mechanisms of activation.
Walker RG, McCoy JC, Czepnik M, Mills MJ, Hagg A, Walton KL, Cotton TR, Hyvönen M, Lee RT, Gregorevic P, Harrison CA, Thompson TB. Walker RG, et al. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E866-E875. doi: 10.1073/pnas.1714622115. Epub 2018 Jan 18. Proc Natl Acad Sci U S A. 2018. PMID: 29348202 Free PMC article.
Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice.
Garbern J, Kristl AC, Bassaneze V, Vujic A, Schoemaker H, Sereda R, Peng L, Ricci-Blair EM, Goldstein JM, Walker RG, Bhasin S, Wagers AJ, Lee RT. Garbern J, et al. Among authors: walker rg. Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H201-H212. doi: 10.1152/ajpheart.00615.2018. Epub 2019 May 24. Am J Physiol Heart Circ Physiol. 2019. PMID: 31125255 Free PMC article.
Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice.
Walker RG, Barrandon O, Poggioli T, Dagdeviren S, Carroll SH, Mills MJ, Mendello KR, Gomez Y, Loffredo FS, Pancoast JR, Macias-Trevino C, Marts C, LeClair KB, Noh HL, Kim T, Banks AS, Kim JK, Cohen DE, Wagers AJ, Melton DA, Lee RT. Walker RG, et al. Sci Rep. 2020 Mar 12;10(1):4561. doi: 10.1038/s41598-020-61443-y. Sci Rep. 2020. PMID: 32165710 Free PMC article.
Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
Lian J, Walker RG, D'Amico A, Vujic A, Mills MJ, Messemer KA, Mendello KR, Goldstein JM, Leacock KA, Epp S, Stimpfl EV, Thompson TB, Wagers AJ, Lee RT. Lian J, et al. Among authors: walker rg. Life Sci Alliance. 2023 Jan 11;6(3):e202201662. doi: 10.26508/lsa.202201662. Print 2023 Mar. Life Sci Alliance. 2023. PMID: 36631218 Free PMC article.
GDF11 and aging biology - controversies resolved and pending.
Driss LB, Lian J, Walker RG, Howard JA, Thompson TB, Rubin LL, Wagers AJ, Lee RT. Driss LB, et al. Among authors: walker rg. J Cardiovasc Aging. 2023 Oct;3(4):42. doi: 10.20517/jca.2023.23. Epub 2023 Oct 20. J Cardiovasc Aging. 2023. PMID: 38235060 Free PMC article.
284 results