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Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.
Cell Chem Biol. 2024 Apr 18;31(4):729-742.e13. doi: 10.1016/j.chembiol.2024.02.008. Epub 2024 Mar 15.
Cell Chem Biol. 2024.
PMID: 38492573
Synthesis and activity of β-carboline antimalarials targeting the Plasmodium falciparum heat shock 90 protein.
Viswanathan NK, Chirgwin ME, Gibbs J, Kalaj BN, Durham S, Tran J, Gomez M, Lazaro H, Chen M, Mansfield CR, Derbyshire ER, Eagon S.
Viswanathan NK, et al. Among authors: chirgwin me.
Bioorg Med Chem Lett. 2023 Aug 15;92:129410. doi: 10.1016/j.bmcl.2023.129410. Epub 2023 Jul 20.
Bioorg Med Chem Lett. 2023.
PMID: 37478957
Free article.
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Labeling strategies to track protozoan parasite proteome dynamics.
Mansfield CR, Chirgwin ME, Derbyshire ER.
Mansfield CR, et al. Among authors: chirgwin me.
Curr Opin Chem Biol. 2023 Aug;75:102316. doi: 10.1016/j.cbpa.2023.102316. Epub 2023 May 14.
Curr Opin Chem Biol. 2023.
PMID: 37192562
Review.
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Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro.
Galal KA, Truong A, Kwarcinski F, de Silva C, Avalani K, Havener TM, Chirgwin ME, Merten E, Ong HW, Willis C, Abdelwaly A, Helal MA, Derbyshire ER, Zutshi R, Drewry DH.
Galal KA, et al. Among authors: chirgwin me.
J Med Chem. 2022 Oct 13;65(19):13172-13197. doi: 10.1021/acs.jmedchem.2c00996. Epub 2022 Sep 27.
J Med Chem. 2022.
PMID: 36166733
Free PMC article.
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Cut it out! A CRISPR-Cas9 screen identifies host regulators of the Plasmodium liver stage.
Chirgwin ME, Schroeder EA, Derbyshire ER.
Chirgwin ME, et al.
Cell Chem Biol. 2022 Sep 15;29(9):1365-1367. doi: 10.1016/j.chembiol.2022.08.005.
Cell Chem Biol. 2022.
PMID: 36113404
Free article.
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Plasmodium's fight for survival: escaping elimination while acquiring nutrients.
Schroeder EA, Chirgwin ME, Derbyshire ER.
Schroeder EA, et al. Among authors: chirgwin me.
Trends Parasitol. 2022 Jul;38(7):544-557. doi: 10.1016/j.pt.2022.04.004. Epub 2022 May 6.
Trends Parasitol. 2022.
PMID: 35534377
Free PMC article.
Review.
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Novel Therapeutic Strategies Applied to Pseudomonas aeruginosa Infections in Cystic Fibrosis.
Chirgwin ME, Dedloff MR, Holban AM, Gestal MC.
Chirgwin ME, et al.
Materials (Basel). 2019 Dec 7;12(24):4093. doi: 10.3390/ma12244093.
Materials (Basel). 2019.
PMID: 31817881
Free PMC article.
Review.
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