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Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model.
Loyola L, Achuthan V, Gilroy K, Borland G, Kilbey A, Mackay N, Bell M, Hay J, Aiyer S, Fingerman D, Villanueva RA, Cameron E, Kozak CA, Engelman AN, Neil J, Roth MJ. Loyola L, et al. Among authors: engelman an. PLoS Pathog. 2019 Dec 9;15(12):e1008154. doi: 10.1371/journal.ppat.1008154. eCollection 2019 Dec. PLoS Pathog. 2019. PMID: 31815961 Free PMC article.
Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.
Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Achuthan V, et al. Among authors: engelman an. Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30. Cell Host Microbe. 2018. PMID: 30173955 Free PMC article.
B-to-A transition in target DNA during retroviral integration.
Jóźwik IK, Li W, Zhang DW, Wong D, Grawenhoff J, Ballandras-Colas A, Aiyer S, Cherepanov P, Engelman AN, Lyumkis D. Jóźwik IK, et al. Among authors: engelman an. Nucleic Acids Res. 2022 Aug 26;50(15):8898-8918. doi: 10.1093/nar/gkac644. Nucleic Acids Res. 2022. PMID: 35947647 Free PMC article.
206 results