Qin A - Search Results

1

Filgotinib, a JAK1 Inhibitor, Has No Effect on QT Interval in Healthy Subjects.

Anderson K, Xin Y, Zheng H, Yun C, Kwan E, Qin A, Namour F, Kearney BP, Mathias A. Anderson K, et al. Among authors: qin a. Clin Pharmacol Drug Dev. 2020 Jan;9(1):32-40. doi: 10.1002/cpdd.755. Epub 2019 Dec 2. Clin Pharmacol Drug Dev. 2020. PMID: 31797578 Clinical Trial.

2

Lack of Drug-Drug Interaction Between Filgotinib, a Selective JAK1 Inhibitor, and Oral Hormonal Contraceptives Levonorgestrel/Ethinyl Estradiol in Healthy Volunteers.

Begley R, Anderson K, Watkins TR, Weng W, Ampaw L, Qin A, Kearney BP, Mathias A. Begley R, et al. Among authors: qin a. Clin Pharmacol Drug Dev. 2021 Apr;10(4):376-383. doi: 10.1002/cpdd.870. Epub 2020 Sep 28. Clin Pharmacol Drug Dev. 2021. PMID: 32989920 Clinical Trial.

3

Evaluation of the potential drug interactions mediated through P-gp, OCT2, and MATE1/2K with filgotinib in healthy subjects.

Hsueh CH, Anderson K, Shen G, Yun C, Qin A, Othman AA. Hsueh CH, et al. Among authors: qin a. Clin Transl Sci. 2022 Feb;15(2):361-370. doi: 10.1111/cts.13152. Epub 2021 Sep 25. Clin Transl Sci. 2022. PMID: 34498807 Free PMC article.

4

The Relative Bioavailability and Effects of Food and Acid-Reducing Agents on Filgotinib Tablets in Healthy Subjects.

Anderson K, Zheng H, Kotecha M, Cuvin J, Scott B, Sharma S, Qin AR, Namour F, Xin Y. Anderson K, et al. Clin Pharmacol Drug Dev. 2019 Jul;8(5):585-594. doi: 10.1002/cpdd.659. Epub 2019 Feb 15. Clin Pharmacol Drug Dev. 2019. PMID: 30768860 Clinical Trial.

5

Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat.

Kirby BJ, Lutz JD, Yue MS, Garrison KL, Qin AR, Ampaw L, Beysen C, Myers RP, Kearney BP, Mathias A. Kirby BJ, et al. Among authors: qin ar. Clin Pharmacol Ther. 2021 May;109(5):1334-1341. doi: 10.1002/cpt.2105. Epub 2020 Nov 25. Clin Pharmacol Ther. 2021. PMID: 33141923 Clinical Trial.

6

Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor.

Choo EF, Woolsey S, DeMent K, Ly J, Messick K, Qin A, Takahashi R. Choo EF, et al. Among authors: qin a. Drug Metab Dispos. 2015 Jun;43(6):864-9. doi: 10.1124/dmd.115.063743. Epub 2015 Mar 26. Drug Metab Dispos. 2015. PMID: 25813936

7

Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.

Ly JQ, Messick K, Qin A, Takahashi RH, Choo EF. Ly JQ, et al. Among authors: qin a. Mol Pharm. 2017 May 1;14(5):1754-1759. doi: 10.1021/acs.molpharmaceut.7b00006. Epub 2017 Apr 7. Mol Pharm. 2017. PMID: 28345929

8

Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS.

Liang X, Yang L, Qin AR, Ly J, Liederer BM, Messick K, Ma S, Zak M, Dragovich PS, Dean BJ, Hop CE, Deng Y. Liang X, et al. Among authors: qin ar. Bioanalysis. 2014 Jun;6(11):1445-57. doi: 10.4155/bio.14.8. Bioanalysis. 2014. PMID: 25046046

9

Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.

O'Brien T, Oeh J, Xiao Y, Liang X, Vanderbilt A, Qin A, Yang L, Lee LB, Ly J, Cosino E, LaCap JA, Ogasawara A, Williams S, Nannini M, Liederer BM, Jackson P, Dragovich PS, Sampath D. O'Brien T, et al. Among authors: qin a. Neoplasia. 2013 Dec;15(12):1314-29. doi: 10.1593/neo.131718. Neoplasia. 2013. PMID: 24403854 Free PMC article.

10

Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti-tumor activity.

Chiang PC, Gould S, Nannini M, Qin A, Deng Y, Arrazate A, Kam KR, Ran Y, Wong H. Chiang PC, et al. Among authors: qin a. Nanoscale Res Lett. 2014 Apr 1;9(1):156. doi: 10.1186/1556-276X-9-156. Nanoscale Res Lett. 2014. PMID: 24685243 Free PMC article.

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