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Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies.
Meng A, Anderson K, Nelson C, Ni L, Chuang SM, Bellanti F, Chang P, Comisar C, Kearney BP, Bartok B, Mathias A. Meng A, et al. Among authors: mathias a. Br J Clin Pharmacol. 2022 Jul;88(7):3211-3221. doi: 10.1111/bcp.15239. Epub 2022 Feb 14. Br J Clin Pharmacol. 2022. PMID: 35072287 Free PMC article. Clinical Trial.
Preclinical Pharmacokinetics and First-in-Human Pharmacokinetics, Safety, and Tolerability of Velpatasvir, a Pangenotypic Hepatitis C Virus NS5A Inhibitor, in Healthy Subjects.
Mogalian E, German P, Kearney BP, Yang CY, Brainard D, Link J, McNally J, Han L, Ling J, Mathias A. Mogalian E, et al. Among authors: mathias a. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02084-16. doi: 10.1128/AAC.02084-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28193657 Free PMC article. Clinical Trial.
Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat.
Kirby BJ, Lutz JD, Yue MS, Garrison KL, Qin AR, Ampaw L, Beysen C, Myers RP, Kearney BP, Mathias A. Kirby BJ, et al. Among authors: mathias a. Clin Pharmacol Ther. 2021 May;109(5):1334-1341. doi: 10.1002/cpt.2105. Epub 2020 Nov 25. Clin Pharmacol Ther. 2021. PMID: 33141923 Clinical Trial.
292 results