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PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.
McLean BA, Zhabyeyev P, Patel VB, Basu R, Parajuli N, DesAulniers J, Murray AG, Kassiri Z, Vanhaesebroeck B, Oudit GY. McLean BA, et al. Among authors: vanhaesebroeck b. Cardiovasc Res. 2015 Mar 1;105(3):292-303. doi: 10.1093/cvr/cvv016. Epub 2015 Jan 24. Cardiovasc Res. 2015. PMID: 25618408
The role of PI3Kα isoform in cardioprotection.
Rossello X, Riquelme JA, He Z, Taferner S, Vanhaesebroeck B, Davidson SM, Yellon DM. Rossello X, et al. Among authors: vanhaesebroeck b. Basic Res Cardiol. 2017 Oct 17;112(6):66. doi: 10.1007/s00395-017-0657-7. Basic Res Cardiol. 2017. PMID: 29043508 Free PMC article.
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
Patel VB, Zhabyeyev P, Chen X, Wang F, Paul M, Fan D, McLean BA, Basu R, Zhang P, Shah S, Dawson JF, Pyle WG, Hazra M, Kassiri Z, Hazra S, Vanhaesebroeck B, McCulloch CA, Oudit GY. Patel VB, et al. Among authors: vanhaesebroeck b. Nat Commun. 2018 Dec 19;9(1):5390. doi: 10.1038/s41467-018-07812-8. Nat Commun. 2018. PMID: 30568254 Free PMC article.
Cracking the context-specific PI3K signaling code.
Madsen RR, Vanhaesebroeck B. Madsen RR, et al. Among authors: vanhaesebroeck b. Sci Signal. 2020 Jan 7;13(613):eaay2940. doi: 10.1126/scisignal.aay2940. Sci Signal. 2020. PMID: 31911433 Review.
218 results