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A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration.
González-Gil I, Zian D, Vázquez-Villa H, Hernández-Torres G, Martínez RF, Khiar-Fernández N, Rivera R, Kihara Y, Devesa I, Mathivanan S, Del Valle CR, Zambrana-Infantes E, Puigdomenech M, Cincilla G, Sanchez-Martinez M, Rodríguez de Fonseca F, Ferrer-Montiel AV, Chun J, López-Vales R, López-Rodríguez ML, Ortega-Gutiérrez S. González-Gil I, et al. Among authors: rodriguez de fonseca f. J Med Chem. 2020 Mar 12;63(5):2372-2390. doi: 10.1021/acs.jmedchem.9b01287. Epub 2019 Dec 16. J Med Chem. 2020. PMID: 31790581 Free PMC article.
Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.
Alvarado M, Goya P, Macías-González M, Pavón FJ, Serrano A, Jagerovic N, Elguero J, Gutiérrez-Rodríguez A, García-Granda S, Suardíaz M, Rodríguez de Fonseca F. Alvarado M, et al. Among authors: rodriguez de fonseca f. Bioorg Med Chem. 2008 Dec 1;16(23):10098-105. doi: 10.1016/j.bmc.2008.10.023. Epub 2008 Oct 14. Bioorg Med Chem. 2008. PMID: 18952442
Chronic immobilization in the malpar1 knockout mice increases oxidative stress in the hippocampus.
García-Fernández M, Castilla-Ortega E, Pedraza C, Blanco E, Hurtado-Guerrero I, Barbancho MA, Chun J, Rodríguez-de-Fonseca F, Estivill-Torrús G, Santín Núñez LJ. García-Fernández M, et al. Among authors: rodriguez de fonseca f. Int J Neurosci. 2012 Oct;122(10):583-9. doi: 10.3109/00207454.2012.693998. Epub 2012 Jun 21. Int J Neurosci. 2012. PMID: 22591409
Fear extinction and acute stress reactivity reveal a role of LPA(1) receptor in regulating emotional-like behaviors.
Pedraza C, Sánchez-López J, Castilla-Ortega E, Rosell-Valle C, Zambrana-Infantes E, García-Fernández M, Rodriguez de Fonseca F, Chun J, Santín LJ, Estivill-Torrús G. Pedraza C, et al. Among authors: rodriguez de fonseca f. Brain Struct Funct. 2014 Sep;219(5):1659-72. doi: 10.1007/s00429-013-0592-9. Epub 2013 Jun 18. Brain Struct Funct. 2014. PMID: 23775489
Reduced wheel running and blunted effects of voluntary exercise in LPA1-null mice: the importance of assessing the amount of running in transgenic mice studies.
Castilla-Ortega E, Rosell-Valle C, Blanco E, Pedraza C, Chun J, Rodríguez de Fonseca F, Estivill-Torrús G, Santín LJ. Castilla-Ortega E, et al. Among authors: rodriguez de fonseca f. Neurosci Res. 2013 Nov;77(3):170-9. doi: 10.1016/j.neures.2013.09.004. Epub 2013 Sep 19. Neurosci Res. 2013. PMID: 24055600 Free PMC article.
Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.
García-Díaz B, Riquelme R, Varela-Nieto I, Jiménez AJ, de Diego I, Gómez-Conde AI, Matas-Rico E, Aguirre JÁ, Chun J, Pedraza C, Santín LJ, Fernández O, Rodríguez de Fonseca F, Estivill-Torrús G. García-Díaz B, et al. Among authors: de diego i, rodriguez de fonseca f. Brain Struct Funct. 2015 Nov;220(6):3701-20. doi: 10.1007/s00429-014-0885-7. Epub 2014 Sep 17. Brain Struct Funct. 2015. PMID: 25226845
Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain.
González de San Román E, Manuel I, Giralt MT, Chun J, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Ferrer I, Rodríguez-Puertas R. González de San Román E, et al. Among authors: rodriguez puertas r, rodriguez de fonseca f. J Neurochem. 2015 Aug;134(3):471-85. doi: 10.1111/jnc.13112. Epub 2015 Apr 27. J Neurochem. 2015. PMID: 25857358 Free PMC article.
Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation.
Fresno N, Macías-González M, Torres-Zaguirre A, Romero-Cuevas M, Sanz-Camacho P, Elguero J, Pavón FJ, Rodríguez de Fonseca F, Goya P, Pérez-Fernández R. Fresno N, et al. Among authors: rodriguez de fonseca f. J Med Chem. 2015 Aug 27;58(16):6639-52. doi: 10.1021/acs.jmedchem.5b00849. Epub 2015 Aug 12. J Med Chem. 2015. PMID: 26226490 Free article.
Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption.
Castilla-Ortega E, Pavón FJ, Sánchez-Marín L, Estivill-Torrús G, Pedraza C, Blanco E, Suárez J, Santín L, Rodríguez de Fonseca F, Serrano A. Castilla-Ortega E, et al. Among authors: rodriguez de fonseca f. Neuropharmacology. 2016 Apr;103:92-103. doi: 10.1016/j.neuropharm.2015.12.010. Epub 2015 Dec 15. Neuropharmacology. 2016. PMID: 26700247
307 results