Unexpected Indirect Dynamics in Base-Induced Elimination.
Meyer J, Carrascosa E, Michaelsen T, Bastian B, Li A, Guo H, Wester R.
Meyer J, et al. Among authors: michaelsen t.
J Am Chem Soc. 2019 Dec 26;141(51):20300-20308. doi: 10.1021/jacs.9b10575. Epub 2019 Dec 12.
J Am Chem Soc. 2019.
PMID: 31782654
The observed mechanistic fingerprints are associated with the E2 reaction, because steric hindrance at the alpha-carbon suppresses the S(N)2 reaction [Carrascosa, E.; Meyer, J.; Zhang, J.; Stei, M.; Michaelsen, T.; Hase, W. L.; Yang, L.; Wester, R. Nat. Commun. 2017 …
The observed mechanistic fingerprints are associated with the E2 reaction, because steric hindrance at the alpha-carbon suppresses the S(N)2 …