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Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H. Fritsch M, et al. Among authors: schiffmann lm. Nature. 2019 Nov;575(7784):683-687. doi: 10.1038/s41586-019-1770-6. Epub 2019 Nov 20. Nature. 2019. PMID: 31748744
Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.
Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H. Coutelle O, et al. Among authors: schiffmann lm. EMBO Mol Med. 2014 May;6(5):624-39. doi: 10.1002/emmm.201303016. EMBO Mol Med. 2014. PMID: 24648500 Free PMC article.
Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer.
Schiffmann LM, Fritsch M, Gebauer F, Günther SD, Stair NR, Seeger JM, Thangarajah F, Dieplinger G, Bludau M, Alakus H, Göbel H, Quaas A, Zander T, Hilberg F, Bruns CJ, Kashkar H, Coutelle O. Schiffmann LM, et al. Br J Cancer. 2019 Jan;120(1):69-78. doi: 10.1038/s41416-018-0198-3. Epub 2018 Oct 31. Br J Cancer. 2019. PMID: 30377339 Free PMC article.
Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma.
Schiffmann LM, Göbel H, Löser H, Schorn F, Werthenbach JP, Fuchs HF, Plum PS, Bludau M, Zander T, Schröder W, Bruns CJ, Kashkar H, Quaas A, Gebauer F. Schiffmann LM, et al. BMC Cancer. 2019 May 31;19(1):531. doi: 10.1186/s12885-019-5722-1. BMC Cancer. 2019. PMID: 31151416 Free PMC article.
Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth.
Schiffmann LM, Werthenbach JP, Heintges-Kleinhofer F, Seeger JM, Fritsch M, Günther SD, Willenborg S, Brodesser S, Lucas C, Jüngst C, Albert MC, Schorn F, Witt A, Moraes CT, Bruns CJ, Pasparakis M, Krönke M, Eming SA, Coutelle O, Kashkar H. Schiffmann LM, et al. Nat Commun. 2020 Jul 21;11(1):3653. doi: 10.1038/s41467-020-17472-2. Nat Commun. 2020. PMID: 32694534 Free PMC article.
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
Daoud M, Broxtermann PN, Schorn F, Werthenbach JP, Seeger JM, Schiffmann LM, Brinkmann K, Vucic D, Tüting T, Mauch C, Kulms D, Zigrino P, Kashkar H. Daoud M, et al. Among authors: schiffmann lm. EMBO Rep. 2022 Jun 7;23(6):e53608. doi: 10.15252/embr.202153608. Epub 2022 Apr 19. EMBO Rep. 2022. PMID: 35437868 Free PMC article.
X-linked inhibitor of apoptosis protein is a prognostic marker for a favorable outcome in three identified subsets in resectable adenocarcinoma of the pancreas.
Knipper K, Lyu SI, Goebel H, Damanakis AI, Zhao Y, Bruns CJ, Schmidt T, Kashkar H, Quaas A, Schiffmann LM, Popp FC; PANCALYZE Study Group. Knipper K, et al. Among authors: schiffmann lm. J Cancer Res Clin Oncol. 2023 Aug;149(9):5531-5538. doi: 10.1007/s00432-022-04476-2. Epub 2022 Dec 6. J Cancer Res Clin Oncol. 2023. PMID: 36472768 Free PMC article.
43 results