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Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H. Fritsch M, et al. Among authors: lamkanfi m. Nature. 2019 Nov;575(7784):683-687. doi: 10.1038/s41586-019-1770-6. Epub 2019 Nov 20. Nature. 2019. PMID: 31748744
Caspase-7: a protease involved in apoptosis and inflammation.
Lamkanfi M, Kanneganti TD. Lamkanfi M, et al. Int J Biochem Cell Biol. 2010 Jan;42(1):21-4. doi: 10.1016/j.biocel.2009.09.013. Epub 2009 Sep 25. Int J Biochem Cell Biol. 2010. PMID: 19782763 Free PMC article. Review.
Non-canonical inflammasome activation targets caspase-11.
Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM. Kayagaki N, et al. Among authors: lamkanfi m. Nature. 2011 Oct 16;479(7371):117-21. doi: 10.1038/nature10558. Nature. 2011. PMID: 22002608
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.
Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, Beyaert R, Elewaut D, Kanneganti TD, van Loo G, Lamkanfi M. Vande Walle L, et al. Among authors: lamkanfi m. Nature. 2014 Aug 7;512(7512):69-73. doi: 10.1038/nature13322. Epub 2014 Jun 29. Nature. 2014. PMID: 25043000 Free PMC article.
Does caspase-12 suppress inflammasome activation?
Vande Walle L, Jiménez Fernández D, Demon D, Van Laethem N, Van Hauwermeiren F, Van Gorp H, Van Opdenbosch N, Kayagaki N, Lamkanfi M. Vande Walle L, et al. Among authors: lamkanfi m. Nature. 2016 Jun 2;534(7605):E1-4. doi: 10.1038/nature17649. Nature. 2016. PMID: 27251234 No abstract available.
Pyroptosis.
Vande Walle L, Lamkanfi M. Vande Walle L, et al. Among authors: lamkanfi m. Curr Biol. 2016 Jul 11;26(13):R568-R572. doi: 10.1016/j.cub.2016.02.019. Curr Biol. 2016. PMID: 27404251 Free article.
Immunology: Gut sensor halts viral attack.
Saavedra PHV, Lamkanfi M. Saavedra PHV, et al. Among authors: lamkanfi m. Nature. 2017 Jun 29;546(7660):606-608. doi: 10.1038/nature23090. Epub 2017 Jun 21. Nature. 2017. PMID: 28636602 No abstract available.
In Retrospect: The inflammasome turns 15.
Lamkanfi M, Dixit VM. Lamkanfi M, et al. Nature. 2017 Aug 30;548(7669):534-535. doi: 10.1038/548534a. Nature. 2017. PMID: 28858314 No abstract available.
156 results