TGF-β-activated kinase-1 inhibitor LL-Z1640-2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF-α and RANKL expression.
Tenshin H, Teramachi J, Ashtar M, Hiasa M, Inoue Y, Oda A, Tanimoto K, Shimizu S, Higa Y, Harada T, Oura M, Sogabe K, Hara T, Sumitani R, Maruhashi T, Sebe M, Tsutsumi R, Sakaue H, Endo I, Matsumoto T, Tanaka E, Abe M.
Tenshin H, et al. Among authors: ashtar m.
Clin Transl Immunology. 2022 Jan 19;11(1):e1371. doi: 10.1002/cti2.1371. eCollection 2022.
Clin Transl Immunology. 2022.
PMID: 35079379
Free PMC article.