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Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
Kaymak I, Maier CR, Schmitz W, Campbell AD, Dankworth B, Ade CP, Walz S, Paauwe M, Kalogirou C, Marouf H, Rosenfeldt MT, Gay DM, McGregor GH, Sansom OJ, Schulze A. Kaymak I, et al. Among authors: schulze a. Cancer Res. 2020 Jan 15;80(2):189-203. doi: 10.1158/0008-5472.CAN-19-0650. Epub 2019 Nov 19. Cancer Res. 2020. PMID: 31744820
SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme.
Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P, Dankworth B, Alibhai D, Harris AL, Schulze A. Lewis CA, et al. Among authors: schulze a. Oncogene. 2015 Oct 1;34(40):5128-40. doi: 10.1038/onc.2014.439. Epub 2015 Jan 26. Oncogene. 2015. PMID: 25619842
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye EO, Critchlow SE, Leung HY, Harris AL, Wakelam MJO, Gottlieb E, Schulze A. Peck B, et al. Among authors: schulze a. Cancer Metab. 2016 Apr 1;4:6. doi: 10.1186/s40170-016-0146-8. eCollection 2016. Cancer Metab. 2016. PMID: 27042297 Free PMC article.
The multifaceted roles of fatty acid synthesis in cancer.
Röhrig F, Schulze A. Röhrig F, et al. Among authors: schulze a. Nat Rev Cancer. 2016 Nov;16(11):732-749. doi: 10.1038/nrc.2016.89. Epub 2016 Sep 23. Nat Rev Cancer. 2016. PMID: 27658529 Review.
Regulation of Metabolic Activity by p53.
Flöter J, Kaymak I, Schulze A. Flöter J, et al. Among authors: schulze a. Metabolites. 2017 May 20;7(2):21. doi: 10.3390/metabo7020021. Metabolites. 2017. PMID: 28531108 Free PMC article. Review.
901 results