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Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
Kaymak I, Maier CR, Schmitz W, Campbell AD, Dankworth B, Ade CP, Walz S, Paauwe M, Kalogirou C, Marouf H, Rosenfeldt MT, Gay DM, McGregor GH, Sansom OJ, Schulze A. Kaymak I, et al. Among authors: kalogirou c. Cancer Res. 2020 Jan 15;80(2):189-203. doi: 10.1158/0008-5472.CAN-19-0650. Epub 2019 Nov 19. Cancer Res. 2020. PMID: 31744820
Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3.
Kneitz B, Krebs M, Kalogirou C, Schubert M, Joniau S, van Poppel H, Lerut E, Kneitz S, Scholz CJ, Ströbel P, Gessler M, Riedmiller H, Spahn M. Kneitz B, et al. Among authors: kalogirou c. Cancer Res. 2014 May 1;74(9):2591-603. doi: 10.1158/0008-5472.CAN-13-1606. Epub 2014 Mar 7. Cancer Res. 2014. PMID: 24607843
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Müller A, Spahn M, Seitz AK, Frank T, Marouf H, Büchel G, Eckstein M, Kübler H, Eilers M, Saar M, Junker K, Röhrig F, Kneitz B, Rosenfeldt MT, Schulze A. Kalogirou C, et al. Nat Commun. 2021 Aug 20;12(1):5066. doi: 10.1038/s41467-021-25325-9. Nat Commun. 2021. PMID: 34417456 Free PMC article.
Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice.
Mainz L, Sarhan MAFE, Roth S, Sauer U, Kalogirou C, Eckstein M, Gerhard-Hartmann E, Seibert HD, Voelker HU, Geppert C, Rosenwald A, Eilers M, Schulze A, Diefenbacher M, Rosenfeldt MT. Mainz L, et al. Among authors: kalogirou c. Autophagy. 2022 Dec;18(12):2880-2893. doi: 10.1080/15548627.2022.2052588. Epub 2022 Mar 28. Autophagy. 2022. PMID: 35343375 Free PMC article.
miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1.
Krebs M, Behrmann C, Kalogirou C, Sokolakis I, Kneitz S, Kruithof-de Julio M, Zoni E, Rech A, Schilling B, Kübler H, Spahn M, Kneitz B. Krebs M, et al. Among authors: kalogirou c. Biomed Res Int. 2019 Nov 14;2019:6392748. doi: 10.1155/2019/6392748. eCollection 2019. Biomed Res Int. 2019. PMID: 31828111 Free PMC article.
54 results