Downs JA - Search Results

1

Defining Signatures of Arm-Wise Copy Number Change and Their Associated Drivers in Kidney Cancers.

Benstead-Hume G, Wooller SK, Downs JA, Pearl FMG. Benstead-Hume G, et al. Among authors: downs ja. Int J Mol Sci. 2019 Nov 16;20(22):5762. doi: 10.3390/ijms20225762. Int J Mol Sci. 2019. PMID: 31744086 Free PMC article.

2

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks.

Benstead-Hume G, Chen X, Hopkins SR, Lane KA, Downs JA, Pearl FMG. Benstead-Hume G, et al. Among authors: downs ja. PLoS Comput Biol. 2019 Apr 17;15(4):e1006888. doi: 10.1371/journal.pcbi.1006888. eCollection 2019 Apr. PLoS Comput Biol. 2019. PMID: 30995217 Free PMC article.

3

Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness.

Schiavoni F, Zuazua-Villar P, Roumeliotis TI, Benstead-Hume G, Pardo M, Pearl FMG, Choudhary JS, Downs JA. Schiavoni F, et al. Among authors: downs ja. Nat Commun. 2022 Apr 1;13(1):1731. doi: 10.1038/s41467-022-29420-3. Nat Commun. 2022. PMID: 35365638 Free PMC article.

4

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability.

Meisenberg C, Pinder SI, Hopkins SR, Wooller SK, Benstead-Hume G, Pearl FMG, Jeggo PA, Downs JA. Meisenberg C, et al. Among authors: downs ja. Mol Cell. 2019 Jan 17;73(2):212-223.e7. doi: 10.1016/j.molcel.2018.11.001. Epub 2018 Dec 13. Mol Cell. 2019. PMID: 30554942 Free PMC article.

5

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.

Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Künzel J, Löbrich M, Jeggo PA, Downs JA. Kakarougkas A, et al. Among authors: downs ja. Mol Cell. 2014 Sep 4;55(5):723-32. doi: 10.1016/j.molcel.2014.06.028. Epub 2014 Jul 24. Mol Cell. 2014. PMID: 25066234 Free PMC article.

6

BAF180 promotes cohesion and prevents genome instability and aneuploidy.

Brownlee PM, Chambers AL, Cloney R, Bianchi A, Downs JA. Brownlee PM, et al. Among authors: downs ja. Cell Rep. 2014 Mar 27;6(6):973-981. doi: 10.1016/j.celrep.2014.02.012. Epub 2014 Mar 6. Cell Rep. 2014. PMID: 24613357 Free PMC article.

7

Chromatin modifiers and remodellers in DNA repair and signalling.

Jeggo PA, Downs JA, Gasser SM. Jeggo PA, et al. Among authors: downs ja. Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731):20160279. doi: 10.1098/rstb.2016.0279. Philos Trans R Soc Lond B Biol Sci. 2017. PMID: 28847816 Free PMC article. No abstract available.

8

Histone isoforms and the oncohistone code.

Flaus A, Downs JA, Owen-Hughes T. Flaus A, et al. Among authors: downs ja. Curr Opin Genet Dev. 2021 Apr;67:61-66. doi: 10.1016/j.gde.2020.11.003. Epub 2020 Dec 4. Curr Opin Genet Dev. 2021. PMID: 33285512 Review.

9

PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance.

Feng H, Lane KA, Roumeliotis TI, Jeggo PA, Somaiah N, Choudhary JS, Downs JA. Feng H, et al. Among authors: downs ja. Genes Dev. 2022 Jul 28;36(13-14):790-806. doi: 10.1101/gad.349249.121. Online ahead of print. Genes Dev. 2022. PMID: 35902118 Free PMC article.

10

Cancer and the bromodomains of BAF180.

Brownlee PM, Chambers AL, Oliver AW, Downs JA. Brownlee PM, et al. Among authors: downs ja. Biochem Soc Trans. 2012 Apr;40(2):364-9. doi: 10.1042/BST20110754. Biochem Soc Trans. 2012. PMID: 22435813 Review.

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