Durrant TN - Search Results

1

Identification of PtdIns(3,4)P₂ effectors in human platelets using quantitative proteomics.

Durrant TN, Moore SF, Bayliss AL, Jiang Y, Aitken EW, Wilson MC, Heesom KJ, Hers I. Durrant TN, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158575. doi: 10.1016/j.bbalip.2019.158575. Epub 2019 Nov 16. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 31743753

2

In-depth PtdIns(3,4,5)P₃ signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ, Anderson KE, Stephens LR, Hawkins PT, Marshall AJ, Moore SF, Hers I. Durrant TN, et al. Blood Adv. 2017 Jun 13;1(14):918-932. doi: 10.1182/bloodadvances.2017005173. Blood Adv. 2017. PMID: 29242851 Free PMC article.

3

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function.

Moore SF, Smith NR, Blair TA, Durrant TN, Hers I. Moore SF, et al. Among authors: durrant tn. Sci Rep. 2019 Feb 6;9(1):1468. doi: 10.1038/s41598-018-37012-9. Sci Rep. 2019. PMID: 30728366 Free PMC article.

4

PI3K inhibitors in thrombosis and cardiovascular disease.

Durrant TN, Hers I. Durrant TN, et al. Clin Transl Med. 2020 Jan 31;9(1):8. doi: 10.1186/s40169-020-0261-6. Clin Transl Med. 2020. PMID: 32002690 Free PMC article. Review.

5

Rapamycin restrains platelet procoagulant responses via FKBP-mediated protection of mitochondrial integrity.

Śledź KM, Moore SF, Durrant TN, Blair TA, Hunter RW, Hers I. Śledź KM, et al. Among authors: durrant tn. Biochem Pharmacol. 2020 Jul;177:113975. doi: 10.1016/j.bcp.2020.113975. Epub 2020 Apr 13. Biochem Pharmacol. 2020. PMID: 32298692

6

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.

Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I. Battram AM, et al. Among authors: durrant tn. J Biol Chem. 2017 Feb 3;292(5):1691-1704. doi: 10.1074/jbc.M116.746867. Epub 2016 Nov 30. J Biol Chem. 2017. PMID: 27903653 Free PMC article.

7

Integrin α_IIbβ₃ outside-in signaling.

Durrant TN, van den Bosch MT, Hers I. Durrant TN, et al. Blood. 2017 Oct 5;130(14):1607-1619. doi: 10.1182/blood-2017-03-773614. Epub 2017 Aug 9. Blood. 2017. PMID: 28794070 Free PMC article. Review.

8

Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation.

Blair TA, Moore SF, Walsh TG, Hutchinson JL, Durrant TN, Anderson KE, Poole AW, Hers I. Blair TA, et al. Among authors: durrant tn. Cell Signal. 2018 Oct;50:111-120. doi: 10.1016/j.cellsig.2018.05.005. Epub 2018 May 21. Cell Signal. 2018. PMID: 29793021

9

A new approach to measuring phosphoinositides in cells by mass spectrometry.

Kielkowska A, Niewczas I, Anderson KE, Durrant TN, Clark J, Stephens LR, Hawkins PT. Kielkowska A, et al. Among authors: durrant tn. Adv Biol Regul. 2014 Jan;54:131-41. doi: 10.1016/j.jbior.2013.09.001. Epub 2013 Sep 17. Adv Biol Regul. 2014. PMID: 24120934 Free article. Review.

10

Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse.

Anderson KE, Kielkowska A, Durrant TN, Juvin V, Clark J, Stephens LR, Hawkins PT. Anderson KE, et al. Among authors: durrant tn. PLoS One. 2013;8(3):e58425. doi: 10.1371/journal.pone.0058425. Epub 2013 Mar 5. PLoS One. 2013. PMID: 23472195 Free PMC article.

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