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Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.
Aragó M, Moreno-Felici J, Abás S, Rodríguez-Arévalo S, Hyroššová P, Figueras A, Viñals F, Pérez B, Loza MI, Brea J, Latorre P, Carrodeguas JA, García-Rovés PM, Galdeano C, Ginex T, Luque FJ, Escolano C, Perales JC. Aragó M, et al. Biomed Pharmacother. 2020 Jan;121:109601. doi: 10.1016/j.biopha.2019.109601. Epub 2019 Nov 15. Biomed Pharmacother. 2020. PMID: 31739159 Free article.
Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells.
Hyroššová P, Aragó M, Muñoz-Pinedo C, Viñals F, García-Rovés PM, Escolano C, Méndez-Lucas A, Perales JC. Hyroššová P, et al. Among authors: garcia roves pm. Cell Death Dis. 2022 Aug 24;13(8):730. doi: 10.1038/s41419-022-05177-x. Cell Death Dis. 2022. PMID: 36002449 Free PMC article.
PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner.
Hyroššová P, Aragó M, Moreno-Felici J, Fu X, Mendez-Lucas A, García-Rovés PM, Burgess S, Figueras A, Viñals F, Perales JC. Hyroššová P, et al. Cancer Metab. 2021 Jan 7;9(1):1. doi: 10.1186/s40170-020-00236-3. Cancer Metab. 2021. PMID: 33413684 Free PMC article.
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.
Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM. Gonzalez-Franquesa A, et al. Among authors: garcia roves pm. Redox Biol. 2022 Aug;54:102353. doi: 10.1016/j.redox.2022.102353. Epub 2022 Jun 24. Redox Biol. 2022. PMID: 35777200 Free PMC article.
Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines.
Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Cosialls AM, Gama-Pérez P, Bhosale G, Mendive-Tapia L, Lavilla R, Pons G, Garcia-Roves PM, Duchen MR, Iglesias-Serret D, Gil J. Saura-Esteller J, et al. Among authors: garcia roves pm. Int J Mol Sci. 2021 Jun 6;22(11):6117. doi: 10.3390/ijms22116117. Int J Mol Sci. 2021. PMID: 34204139 Free PMC article.
Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate.
Huber-Ruano I, Calvo E, Mayneris-Perxachs J, Rodríguez-Peña MM, Ceperuelo-Mallafré V, Cedó L, Núñez-Roa C, Miro-Blanch J, Arnoriaga-Rodríguez M, Balvay A, Maudet C, García-Roves P, Yanes O, Rabot S, Grimaud GM, De Prisco A, Amoruso A, Fernández-Real JM, Vendrell J, Fernández-Veledo S. Huber-Ruano I, et al. Microbiome. 2022 Aug 25;10(1):135. doi: 10.1186/s40168-022-01306-y. Microbiome. 2022. PMID: 36002880 Free PMC article.
74 results