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Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.
Tanaka A, Nishikawa H, Noguchi S, Sugiyama D, Morikawa H, Takeuchi Y, Ha D, Shigeta N, Kitawaki T, Maeda Y, Saito T, Shinohara Y, Kameoka Y, Iwaisako K, Monma F, Ohishi K, Karbach J, Jäger E, Sawada K, Katayama N, Takahashi N, Sakaguchi S. Tanaka A, et al. Among authors: saito t. J Exp Med. 2020 Feb 3;217(2):e20191009. doi: 10.1084/jem.20191009. J Exp Med. 2020. PMID: 31704808 Free PMC article.
Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab.
Maeda Y, Wada H, Sugiyama D, Saito T, Irie T, Itahashi K, Minoura K, Suzuki S, Kojima T, Kakimi K, Nakajima J, Funakoshi T, Iida S, Oka M, Shimamura T, Doi T, Doki Y, Nakayama E, Ueda R, Nishikawa H. Maeda Y, et al. Among authors: saito t. Nat Commun. 2021 Dec 14;12(1):7280. doi: 10.1038/s41467-021-27574-0. Nat Commun. 2021. PMID: 34907192 Free PMC article. Clinical Trial.
Neural-net-based cell deconvolution from DNA methylation reveals tumor microenvironment associated with cancer prognosis.
Yasumizu Y, Hagiwara M, Umezu Y, Fuji H, Iwaisako K, Asagiri M, Uemoto S, Nakamura Y, Thul S, Ueyama A, Yokoi K, Tanemura A, Nose Y, Saito T, Wada H, Kakuda M, Kohara M, Nojima S, Morii E, Doki Y, Sakaguchi S, Ohkura N. Yasumizu Y, et al. Among authors: saito t. NAR Cancer. 2024 May 15;6(2):zcae022. doi: 10.1093/narcan/zcae022. eCollection 2024 Jun. NAR Cancer. 2024. PMID: 38751935 Free PMC article.
Targeted therapy for drug-tolerant persister cells after imatinib treatment for gastrointestinal stromal tumours.
Ishida T, Takahashi T, Kurokawa Y, Nishida T, Hirota S, Serada S, Fujimoto M, Naka T, Teranishi R, Saito T, Yamashita K, Tanaka K, Yamamoto K, Makino T, Yamasaki M, Nakajima K, Eguchi H, Doki Y. Ishida T, et al. Among authors: saito t. Br J Cancer. 2021 Nov;125(11):1511-1522. doi: 10.1038/s41416-021-01566-9. Epub 2021 Oct 5. Br J Cancer. 2021. PMID: 34611306 Free PMC article.
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