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A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
Nat Cell Biol. 2019 Nov;21(11):1413-1424. doi: 10.1038/s41556-019-0408-0. Epub 2019 Nov 4.
Nat Cell Biol. 2019.
PMID: 31685988
Free PMC article.
Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.
Wiegering A, Uthe FW, Jamieson T, Ruoss Y, Hüttenrauch M, Küspert M, Pfann C, Nixon C, Herold S, Walz S, Taranets L, Germer CT, Rosenwald A, Sansom OJ, Eilers M.
Wiegering A, et al. Among authors: uthe fw.
Cancer Discov. 2015 Jul;5(7):768-781. doi: 10.1158/2159-8290.CD-14-1040. Epub 2015 May 1.
Cancer Discov. 2015.
PMID: 25934076
Free PMC article.
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CIP2A influences survival in colon cancer and is critical for maintaining Myc expression.
Wiegering A, Pfann C, Uthe FW, Otto C, Rycak L, Mäder U, Gasser M, Waaga-Gasser AM, Eilers M, Germer CT.
Wiegering A, et al. Among authors: uthe fw.
PLoS One. 2013 Oct 1;8(10):e75292. doi: 10.1371/journal.pone.0075292. eCollection 2013.
PLoS One. 2013.
PMID: 24098375
Free PMC article.
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The impact of pyrvinium pamoate on colon cancer cell viability.
Wiegering A, Uthe FW, Hüttenrauch M, Mühling B, Linnebacher M, Krummenast F, Germer CT, Thalheimer A, Otto C.
Wiegering A, et al. Among authors: uthe fw.
Int J Colorectal Dis. 2014 Oct;29(10):1189-98. doi: 10.1007/s00384-014-1975-y. Epub 2014 Jul 26.
Int J Colorectal Dis. 2014.
PMID: 25060218
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Diagnostic value of preoperative CT scan to stratify colon cancer for neoadjuvant therapy.
Wiegering A, Kunz M, Hussein M, Klein I, Wiegering V, Uthe FW, Dietz UA, Jurowich C, Bley T, Dandekar T, Germer CT, Ritter C.
Wiegering A, et al. Among authors: uthe fw.
Int J Colorectal Dis. 2015 Aug;30(8):1067-73. doi: 10.1007/s00384-015-2265-z. Epub 2015 May 22.
Int J Colorectal Dis. 2015.
PMID: 25997602
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