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Sustained GRK2-dependent CREB activation is essential for α2-adrenergic receptor-induced PC12 neuronal differentiation.
Cell Signal. 2020 Feb;66:109446. doi: 10.1016/j.cellsig.2019.109446. Epub 2019 Oct 31.
Cell Signal. 2020.
PMID: 31678682
Alpha 2-adrenergic receptors decrease DNA replication and cell proliferation and induce neurite outgrowth in transfected rat pheochromocytoma cells.
Karkoulias G, Mastrogianni O, Ilias I, Lymperopoulos A, Taraviras S, Tsopanoglou N, Sitaras N, Flordellis CS.
Karkoulias G, et al.
Ann N Y Acad Sci. 2006 Nov;1088:335-45. doi: 10.1196/annals.1366.017.
Ann N Y Acad Sci. 2006.
PMID: 17192578
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The polymorphic deleted-form of the human α2B-adrenergic receptor and its wild-type counterpart display post-receptor signaling pathway differences in LLC-PK1 cells.
Mastrogianni O, Crassous PA, Karkoulias G, Lykouras D, Schaak S, Patsouras N, Panayiotakopoulos G, Sivolapenko G, Paris H, Manolis AS, Flordellis C.
Mastrogianni O, et al. Among authors: karkoulias g.
Hellenic J Cardiol. 2016 Aug 20:S1109-9666(16)30156-7. doi: 10.1016/j.hjc.2016.05.009. Online ahead of print.
Hellenic J Cardiol. 2016.
PMID: 27729182
Free article.
No abstract available.
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Alpha2-adrenergic receptors activate cyclic AMP-response element-binding protein through arachidonic acid metabolism and protein kinase A in a subtype-specific manner.
Karkoulias G, Mastrogianni O, Papathanasopoulos P, Paris H, Flordellis C.
Karkoulias G, et al.
J Neurochem. 2007 Nov;103(3):882-95. doi: 10.1111/j.1471-4159.2007.04852.x. Epub 2007 Aug 6.
J Neurochem. 2007.
PMID: 17680988
Free article.
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Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells.
Karkoulias G, Flordellis C.
Karkoulias G, et al.
Cell Signal. 2007 May;19(5):945-57. doi: 10.1016/j.cellsig.2006.11.003. Epub 2006 Nov 21.
Cell Signal. 2007.
PMID: 17215105
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Alpha2-adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cells.
Lymperopoulos A, Karkoulias G, Koch WJ, Flordellis CS.
Lymperopoulos A, et al. Among authors: karkoulias g.
Neurosci Lett. 2006 Jul 24;402(3):210-5. doi: 10.1016/j.neulet.2006.03.066. Epub 2006 May 24.
Neurosci Lett. 2006.
PMID: 16730120
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alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.
Karkoulias G, Mastrogianni O, Lymperopoulos A, Paris H, Flordellis C.
Karkoulias G, et al.
Cell Signal. 2006 May;18(5):729-39. doi: 10.1016/j.cellsig.2005.06.014. Epub 2005 Aug 10.
Cell Signal. 2006.
PMID: 16098714
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