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Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia.
Patil P, Cieslak A, Bernhart SH, Toprak UH, Wagener R, López C, Wiehle L, Bens S, Altmüller J, Franitza M, Scholz I, Jayne S, Ahearne MJ, Scheffold A, Jebaraj BMC, Schneider C, Costa D, Braun T, Schrader A, Campo E, Dyer MJS, Nürnberg P, Dürig J, Johansson P, Böttcher S, Schlesner M, Herling M, Stilgenbauer S, Macintyre E, Siebert R. Patil P, et al. Among authors: wiehle l. Genes Chromosomes Cancer. 2020 Apr;59(4):261-267. doi: 10.1002/gcc.22821. Epub 2019 Nov 29. Genes Chromosomes Cancer. 2020. PMID: 31677197
T-cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level.
Patil P, Hillebrecht S, Chteinberg E, López C, Toprak UH, Seufert J, Bernhart SH, Kretzmer H, Bergmann AK, Bens S, Högel J, Müller A, Jebaraj BM, Schrader A, Johansson P, Costa D, Schlesner M, Dürig J, Herling M, Campo E, Stilgenbauer S, Wiehle L, Siebert R. Patil P, et al. Among authors: wiehle l. Genes Chromosomes Cancer. 2022 Jul;61(7):432-436. doi: 10.1002/gcc.23034. Epub 2022 Mar 29. Genes Chromosomes Cancer. 2022. PMID: 35218115
Exploration of whole genome and transcriptome sequencing data lacks evidence for oncogenic viral elements to drive the pathogenesis of T-cell prolymphocytic leukemia.
Patil P, Toprak UH, Seufert J, Braun T, Bernhart SH, Wiehle L, Müller A, Schlesner M, Herling M, Lichter P, Stilgenbauer S, Siebert R, Zapatka M. Patil P, et al. Among authors: wiehle l. Leuk Lymphoma. 2022 Dec;63(13):3253-3256. doi: 10.1080/10428194.2022.2116933. Epub 2022 Sep 9. Leuk Lymphoma. 2022. PMID: 36083597 No abstract available.
Loss of function mutations of BCOR in classical Hodgkin lymphoma.
Giefing M, Gearhart MD, Schneider M, Overbeck B, Klapper W, Hartmann S, Ustaszewski A, Weniger MA, Wiehle L, Hansmann ML, Melnick A, Béguelin W, Sundström C, Küppers R, Bardwell VJ, Siebert R. Giefing M, et al. Among authors: wiehle l. Leuk Lymphoma. 2022 May;63(5):1080-1090. doi: 10.1080/10428194.2021.2015587. Epub 2021 Dec 27. Leuk Lymphoma. 2022. PMID: 34957890
Chromatin Immunoprecipitation.
Wiehle L, Breiling A. Wiehle L, et al. Methods Mol Biol. 2016;1480:7-21. doi: 10.1007/978-1-4939-6380-5_2. Methods Mol Biol. 2016. PMID: 27659971
Wildlife as Sentinels of Antimicrobial Resistance in Germany?
Plaza-Rodríguez C, Alt K, Grobbel M, Hammerl JA, Irrgang A, Szabo I, Stingl K, Schuh E, Wiehle L, Pfefferkorn B, Naumann S, Kaesbohrer A, Tenhagen BA. Plaza-Rodríguez C, et al. Among authors: wiehle l. Front Vet Sci. 2021 Jan 27;7:627821. doi: 10.3389/fvets.2020.627821. eCollection 2020. Front Vet Sci. 2021. PMID: 33585611 Free PMC article.
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