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Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants.
Jaeggi T, Kortman GA, Moretti D, Chassard C, Holding P, Dostal A, Boekhorst J, Timmerman HM, Swinkels DW, Tjalsma H, Njenga J, Mwangi A, Kvalsvig J, Lacroix C, Zimmermann MB. Jaeggi T, et al. Among authors: boekhorst j. Gut. 2015 May;64(5):731-42. doi: 10.1136/gutjnl-2014-307720. Epub 2014 Aug 20. Gut. 2015. PMID: 25143342 Clinical Trial.
Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens.
Kortman GA, Mulder ML, Richters TJ, Shanmugam NK, Trebicka E, Boekhorst J, Timmerman HM, Roelofs R, Wiegerinck ET, Laarakkers CM, Swinkels DW, Bolhuis A, Cherayil BJ, Tjalsma H. Kortman GA, et al. Among authors: boekhorst j. Eur J Immunol. 2015 Sep;45(9):2553-67. doi: 10.1002/eji.201545642. Epub 2015 Jun 23. Eur J Immunol. 2015. PMID: 26046550 Free PMC article.
Microbial Metabolism Shifts Towards an Adverse Profile with Supplementary Iron in the TIM-2 In vitro Model of the Human Colon.
Kortman GA, Dutilh BE, Maathuis AJ, Engelke UF, Boekhorst J, Keegan KP, Nielsen FG, Betley J, Weir JC, Kingsbury Z, Kluijtmans LA, Swinkels DW, Venema K, Tjalsma H. Kortman GA, et al. Among authors: boekhorst j. Front Microbiol. 2016 Jan 6;6:1481. doi: 10.3389/fmicb.2015.01481. eCollection 2015. Front Microbiol. 2016. PMID: 26779139 Free PMC article.
Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: a randomised controlled study in Kenyan infants.
Paganini D, Uyoga MA, Kortman GAM, Cercamondi CI, Moretti D, Barth-Jaeggi T, Schwab C, Boekhorst J, Timmerman HM, Lacroix C, Karanja S, Zimmermann MB. Paganini D, et al. Among authors: boekhorst j. Gut. 2017 Nov;66(11):1956-1967. doi: 10.1136/gutjnl-2017-314418. Epub 2017 Aug 3. Gut. 2017. PMID: 28774885 Clinical Trial.
Intestinal colonisation patterns in breastfed and formula-fed infants during the first 12 weeks of life reveal sequential microbiota signatures.
Timmerman HM, Rutten NBMM, Boekhorst J, Saulnier DM, Kortman GAM, Contractor N, Kullen M, Floris E, Harmsen HJM, Vlieger AM, Kleerebezem M, Rijkers GT. Timmerman HM, et al. Among authors: boekhorst j. Sci Rep. 2017 Aug 21;7(1):8327. doi: 10.1038/s41598-017-08268-4. Sci Rep. 2017. PMID: 28827640 Free PMC article.
Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI-induced hypomagnesemia.
Gommers LMM, Ederveen THA, van der Wijst J, Overmars-Bos C, Kortman GAM, Boekhorst J, Bindels RJM, de Baaij JHF, Hoenderop JGJ. Gommers LMM, et al. Among authors: boekhorst j. FASEB J. 2019 Oct;33(10):11235-11246. doi: 10.1096/fj.201900839R. Epub 2019 Jul 12. FASEB J. 2019. PMID: 31299175
Together, these results imply that both omeprazole treatment and low dietary Mg(2+) intake disturb the gut internal milieu and may pose a risk for the malabsorption of Mg(2+) in the colon.-Gommers, L. M. M., Ederveen, T. H. A., van der Wijst, J., Overmars-Bos, C., Kortman, …
Together, these results imply that both omeprazole treatment and low dietary Mg(2+) intake disturb the gut internal milieu and may pose a ri …
Multi-Nutrient Fortified Dairy-Based Drink Reduces Anaemia without Observed Adverse Effects on Gut Microbiota in Anaemic Malnourished Nigerian Toddlers: A Randomised Dose-Response Study.
Owolabi AJ, Senbanjo IO, Oshikoya KA, Boekhorst J, Eijlander RT, Kortman GAM, Hageman JHJ, Samuel F, Melse-Boonstra A, Schaafsma A. Owolabi AJ, et al. Among authors: boekhorst j. Nutrients. 2021 May 6;13(5):1566. doi: 10.3390/nu13051566. Nutrients. 2021. PMID: 34066577 Free PMC article. Clinical Trial.
110 results