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PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.
Elife. 2019 Oct 30;8:e50416. doi: 10.7554/eLife.50416.
Elife. 2019.
PMID: 31663853
Free PMC article.
Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
Sobu Y, Wawro PS, Dhekne HS, Yeshaw WM, Pfeffer SR.
Sobu Y, et al. Among authors: yeshaw wm.
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2005894118. doi: 10.1073/pnas.2005894118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33653948
Free PMC article.
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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
Dhekne HS, Tonelli F, Yeshaw WM, Chiang CY, Limouse C, Jaimon E, Purlyte E, Alessi DR, Pfeffer SR.
Dhekne HS, et al. Among authors: yeshaw wm.
Elife. 2023 Oct 24;12:e87098. doi: 10.7554/eLife.87098.
Elife. 2023.
PMID: 37874635
Free PMC article.
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Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.
Yeshaw WM, Adhikari A, Chiang CY, Dhekne HS, Wawro PS, Pfeffer SR.
Yeshaw WM, et al.
Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2315171120. doi: 10.1073/pnas.2315171120. Epub 2023 Oct 27.
Proc Natl Acad Sci U S A. 2023.
PMID: 37889931
Free PMC article.
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Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.
Yeshaw WM, van der Zwaag M, Pinto F, Lahaye LL, Faber AI, Gómez-Sánchez R, Dolga AM, Poland C, Monaco AP, van IJzendoorn SC, Grzeschik NA, Velayos-Baeza A, Sibon OC.
Yeshaw WM, et al.
Elife. 2019 Feb 11;8:e43561. doi: 10.7554/eLife.43561.
Elife. 2019.
PMID: 30741634
Free PMC article.
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Drosophila Vps13 Is Required for Protein Homeostasis in the Brain.
Vonk JJ, Yeshaw WM, Pinto F, Faber AI, Lahaye LL, Kanon B, van der Zwaag M, Velayos-Baeza A, Freire R, van IJzendoorn SC, Grzeschik NA, Sibon OC.
Vonk JJ, et al. Among authors: yeshaw wm.
PLoS One. 2017 Jan 20;12(1):e0170106. doi: 10.1371/journal.pone.0170106. eCollection 2017.
PLoS One. 2017.
PMID: 28107480
Free PMC article.
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HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release.
Miskiewicz K, Jose LE, Yeshaw WM, Valadas JS, Swerts J, Munck S, Feiguin F, Dermaut B, Verstreken P.
Miskiewicz K, et al. Among authors: yeshaw wm.
Cell Rep. 2014 Jul 10;8(1):94-102. doi: 10.1016/j.celrep.2014.05.051. Epub 2014 Jun 26.
Cell Rep. 2014.
PMID: 24981865
Free article.
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Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.
Pal P, Taylor M, Lam PY, Tonelli F, Hecht CA, Lis P, Nirujogi RS, Phung TK, Yeshaw WM, Jaimon E, Fasimoye R, Dickie EA, Wightman M, Macartney T, Pfeffer SR, Alessi DR.
Pal P, et al. Among authors: yeshaw wm.
Sci Adv. 2023 Dec 15;9(50):eadj1205. doi: 10.1126/sciadv.adj1205. Epub 2023 Dec 13.
Sci Adv. 2023.
PMID: 38091401
Free PMC article.
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