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The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.
O'Hara SP, Splinter PL, Trussoni CE, Guicciardi ME, Splinter NP, Al Suraih MS, Nasser-Ghodsi N, Stollenwerk D, Gores GJ, LaRusso NF. O'Hara SP, et al. Among authors: splinter np. J Biol Chem. 2019 Dec 6;294(49):18698-18713. doi: 10.1074/jbc.RA119.010176. Epub 2019 Oct 28. J Biol Chem. 2019. PMID: 31659122 Free PMC article.
Monoclonal gammopathy of thrombotic/thrombocytopenic significance.
Kanack AJ, Schaefer JK, Sridharan M, Splinter NP, Kohlhagen MC, Singh B, De Lorenzo SB, Mauch EE, Hussein MA, Shaikh M, Kumar S, Wen R, Wang D, Murray D, Padmanabhan A. Kanack AJ, et al. Among authors: splinter np. Blood. 2023 Apr 6;141(14):1772-1776. doi: 10.1182/blood.2022018797. Blood. 2023. PMID: 36626584 Free PMC article. No abstract available.
Off-the-shelf cryopreserved platelets for the detection of HIT and VITT antibodies.
Kanack AJ, Jones CG, Singh B, Leger RR, Splinter NP, Heikal NM, Pruthi RK, Chen D, George G, Abou-Ismail MY, Wool GD, Gundabolu K, Padmanabhan A. Kanack AJ, et al. Among authors: splinter np. Blood. 2022 Dec 22;140(25):2722-2729. doi: 10.1182/blood.2022017283. Blood. 2022. PMID: 35998675 Free PMC article.
Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT.
Kanack AJ, Bayas A, George G, Abou-Ismail MY, Singh B, Kohlhagen MC, Splinter NP, Christ M, Naumann M, Moser KA, Smock KJ, Grazioli A, Wen R, Wang D, Murray DL, Padmanabhan A. Kanack AJ, et al. Among authors: splinter np. Blood. 2022 Jul 7;140(1):73-77. doi: 10.1182/blood.2021014588. Blood. 2022. PMID: 35560046 Free PMC article.