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The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.
J Biol Chem. 2019 Dec 6;294(49):18698-18713. doi: 10.1074/jbc.RA119.010176. Epub 2019 Oct 28.
J Biol Chem. 2019.
PMID: 31659122
Free PMC article.
Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.
Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC.
Moncsek A, et al. Among authors: al suraih ms.
Hepatology. 2018 Jan;67(1):247-259. doi: 10.1002/hep.29464. Epub 2017 Nov 29.
Hepatology. 2018.
PMID: 28802066
Free PMC article.
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Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.
Al Suraih MS, Trussoni CE, Splinter PL, LaRusso NF, O'Hara SP.
Al Suraih MS, et al.
Liver Int. 2020 Oct;40(10):2455-2468. doi: 10.1111/liv.14569. Epub 2020 Jul 7.
Liver Int. 2020.
PMID: 32558183
Free PMC article.
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Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2 -/- mouse.
Alsuraih M, O'Hara SP, Woodrum JE, Pirius NE, LaRusso NF.
Alsuraih M, et al.
JHEP Rep. 2021 Jan 27;3(3):100250. doi: 10.1016/j.jhepr.2021.100250. eCollection 2021 Jun.
JHEP Rep. 2021.
PMID: 33870156
Free PMC article.
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Management of renal artery stenosis: What does the experimental evidence tell us?
Al-Suraih M, Grande JP.
Al-Suraih M, et al.
World J Cardiol. 2014 Aug 26;6(8):855-60. doi: 10.4330/wjc.v6.i8.855.
World J Cardiol. 2014.
PMID: 25228964
Free PMC article.
Review.
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